HXCBA_DANRE
ID HXCBA_DANRE Reviewed; 306 AA.
AC Q58EL0; O57366; Q4PR85; Q9YGT2;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Homeobox protein Hox-C11a;
GN Name=hoxc11a {ECO:0000312|EMBL:AAH91858.1,
GN ECO:0000312|ZFIN:ZDB-GENE-990415-111}; ORFNames=zgc:110834;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1] {ECO:0000312|EMBL:AAH91858.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000312|EMBL:AAH91858.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAY67936.1}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 69-289.
RC STRAIN=Tuebingen {ECO:0000269|PubMed:16174031};
RX PubMed=16174031; DOI=10.1111/j.1525-142x.2005.05042.x;
RA Corredor-Adamez M., Welten M.C.M., Spaink H.P., Jeffery J.E., Schoon R.T.,
RA de Bakker M.A.G., Bagowski C.P., Meijer A.H., Verbeek F.J.,
RA Richardson M.K.;
RT "Genomic annotation and transcriptome analysis of the zebrafish (Danio
RT rerio) hox complex with description of a novel member, hoxb13a.";
RL Evol. Dev. 7:362-375(2005).
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAD15951.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 234-305.
RX PubMed=9831563; DOI=10.1126/science.282.5394.1711;
RA Amores A., Force A., Yan Y.-L., Joly L., Amemiya C., Fritz A., Ho R.K.,
RA Langeland J., Prince V.E., Wang Y.-L., Westerfield M., Ekker M.,
RA Postlethwait J.H.;
RT "Zebrafish hox clusters and vertebrate genome evolution.";
RL Science 282:1711-1714(1998).
RN [4] {ECO:0000305, ECO:0000312|EMBL:CAA74876.1}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 257-306.
RC TISSUE=Embryo {ECO:0000269|PubMed:9425136};
RX PubMed=9425136; DOI=10.1242/dev.125.3.407;
RA Prince V.E., Joly L., Ekker M., Ho R.K.;
RT "Zebrafish hox genes: genomic organization and modified colinear expression
RT patterns in the trunk.";
RL Development 125:407-420(1998).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC {ECO:0000250|UniProtKB:O43248}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O43248,
CC ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000255}.
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DR EMBL; BC091858; AAH91858.1; -; mRNA.
DR EMBL; DQ060558; AAY67936.1; -; mRNA.
DR EMBL; AF071258; AAD15951.1; -; Genomic_DNA.
DR EMBL; Y14541; CAA74876.1; -; mRNA.
DR RefSeq; NP_571240.1; NM_131165.2.
DR AlphaFoldDB; Q58EL0; -.
DR SMR; Q58EL0; -.
DR STRING; 7955.ENSDARP00000093920; -.
DR PaxDb; Q58EL0; -.
DR Ensembl; ENSDART00000103146; ENSDARP00000093920; ENSDARG00000070351.
DR GeneID; 30403; -.
DR KEGG; dre:30403; -.
DR CTD; 30403; -.
DR ZFIN; ZDB-GENE-990415-111; hoxc11a.
DR eggNOG; KOG0487; Eukaryota.
DR GeneTree; ENSGT00940000160009; -.
DR InParanoid; Q58EL0; -.
DR OrthoDB; 976319at2759; -.
DR PhylomeDB; Q58EL0; -.
DR TreeFam; TF350668; -.
DR PRO; PR:Q58EL0; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 23.
DR Bgee; ENSDARG00000070351; Expressed in tail bud paraxial mesoderm and 19 other tissues.
DR ExpressionAtlas; Q58EL0; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR021918; DUF3528.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF12045; DUF3528; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..306
FT /note="Homeobox protein Hox-C11a"
FT /id="PRO_0000248836"
FT DNA_BIND 234..293
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 177..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..192
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 195..209
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 210..229
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 259
FT /note="I -> M (in Ref. 4; CAA74876)"
FT /evidence="ECO:0000305"
FT CONFLICT 301
FT /note="S -> W (in Ref. 4; CAA74876)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 306 AA; 35169 MW; 6953CC6293A845EC CRC64;
MFNSVNLGNF CSQTRKDRTS EFGDRTGCAS NIYLPSCTYY VPEFSAVSSF LPQGPSRQIT
YPYSTNLSQV QPVRDVSYGL DPSSKWHHRS NYASCYSGED LVHRDCLPPS TMTEMLMKNE
SVYSHHHQHH PNSSHPSTGF YTGVGKNNVL PQGFDRFFET AYCSTDNQSE HCLQKSEMNK
LETSSQQPTA VSAAREPEKD PEDEEEHTNS GSCTSAATKD GNASKSSHSS TPRTRKKRCP
YSKFQIRELE REFFFNVYIN KEKRLQLSRM LNLTDRQVKI WFQNRRMKEK KLSRDRLQYF
SGNPLL
