ID   HXCBA_TAKRU             Reviewed;         322 AA.
AC   Q1KKV2;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Homeobox protein Hox-C11a;
GN   Name=hoxc11a;
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16636282; DOI=10.1073/pnas.0601492103;
RA   Lee A.P., Koh E.G.L., Tay A., Brenner S., Venkatesh B.;
RT   "Highly conserved syntenic blocks at the vertebrate Hox loci and conserved
RT   regulatory elements within and outside Hox gene clusters.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:6994-6999(2006).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
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DR   EMBL; DQ481667; ABF22442.1; -; Genomic_DNA.
DR   RefSeq; XP_003963116.1; XM_003963067.2.
DR   AlphaFoldDB; Q1KKV2; -.
DR   SMR; Q1KKV2; -.
DR   STRING; 31033.ENSTRUP00000009758; -.
DR   Ensembl; ENSTRUT00000086989; ENSTRUP00000078380; ENSTRUG00000004120.
DR   GeneID; 101079125; -.
DR   KEGG; tru:101079125; -.
DR   CTD; 30403; -.
DR   eggNOG; KOG0487; Eukaryota.
DR   GeneTree; ENSGT00940000160009; -.
DR   HOGENOM; CLU_079662_0_0_1; -.
DR   InParanoid; Q1KKV2; -.
DR   OrthoDB; 976319at2759; -.
DR   Proteomes; UP000005226; Chromosome 3.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR021918; DUF3528.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF12045; DUF3528; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..322
FT                   /note="Homeobox protein Hox-C11a"
FT                   /id="PRO_0000265991"
FT   DNA_BIND        250..309
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          121..141
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          174..255
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        174..205
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        220..245
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   322 AA;  36534 MW;  05DA13F11E237A3F CRC64;
     MFNSVNLGNF CSQTRKDRTS EFGDRTGCAS NIYLPSCTYY VPEFSAVSSF LPQATSRQIS
     YPYSTNLSQV QPVRDVSYGL DPASKWHRSN YASCYSGEDL VHRDCLPPST MTEMLMKNES
     VYSHHHHHHT HPGSNHPSAG FYSGVGKNNV LPQGFDRFFE TAYCSSTDNQ SDICLQKGEG
     GKQESDSQQP QQPQQQRQQP SAALAGASEQ EKDPGDEEEQ TNSGSCSTSS PAATKEGNAG
     KSSHSSTPRT RKKRCPYSKF QIRELEREFF FNVYINKEKR LQLSRMLNLT DRQVKIWFQN
     RRMKEKKLSR DRLQYFSGNP LL