ID   HXCCB_DANRE             Reviewed;         283 AA.
AC   Q9YGT0; Q4PR80;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Homeobox protein Hox-C12b;
GN   Name=hoxc12b;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9831563; DOI=10.1126/science.282.5394.1711;
RA   Amores A., Force A., Yan Y.-L., Joly L., Amemiya C., Fritz A., Ho R.K.,
RA   Langeland J., Prince V.E., Wang Y.-L., Westerfield M., Ekker M.,
RA   Postlethwait J.H.;
RT   "Zebrafish hox clusters and vertebrate genome evolution.";
RL   Science 282:1711-1714(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 104-216.
RC   STRAIN=Tuebingen;
RX   PubMed=16174031; DOI=10.1111/j.1525-142x.2005.05042.x;
RA   Corredor-Adamez M., Welten M.C.M., Spaink H.P., Jeffery J.E., Schoon R.T.,
RA   de Bakker M.A.G., Bagowski C.P., Meijer A.H., Verbeek F.J.,
RA   Richardson M.K.;
RT   "Genomic annotation and transcriptome analysis of the zebrafish (Danio
RT   rerio) hox complex with description of a novel member, hoxb13a.";
RL   Evol. Dev. 7:362-375(2005).
RN   [3]
RP   DEVELOPMENTAL STAGE.
RX   PubMed=15385162; DOI=10.1016/j.ydbio.2004.07.018;
RA   Thummel R., Li L., Tanase C., Sarras M.P. Jr., Godwin A.R.;
RT   "Differences in expression pattern and function between zebrafish hoxc13
RT   orthologs: recruitment of Hoxc13b into an early embryonic role.";
RL   Dev. Biol. 274:318-333(2004).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically, from
CC       ova through to 48 hours post-fertilization.
CC       {ECO:0000269|PubMed:15385162}.
CC   -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
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DR   EMBL; AF071260; AAD15953.1; -; Genomic_DNA.
DR   EMBL; DQ060563; AAY67941.1; -; mRNA.
DR   RefSeq; NP_571620.1; NM_131545.1.
DR   AlphaFoldDB; Q9YGT0; -.
DR   SMR; Q9YGT0; -.
DR   STRING; 7955.ENSDARP00000067695; -.
DR   PaxDb; Q9YGT0; -.
DR   GeneID; 58062; -.
DR   KEGG; dre:58062; -.
DR   CTD; 58062; -.
DR   ZFIN; ZDB-GENE-000329-17; hoxc12b.
DR   eggNOG; KOG0487; Eukaryota.
DR   InParanoid; Q9YGT0; -.
DR   OrthoDB; 1154178at2759; -.
DR   PhylomeDB; Q9YGT0; -.
DR   PRO; PR:Q9YGT0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..283
FT                   /note="Homeobox protein Hox-C12b"
FT                   /id="PRO_0000200196"
FT   DNA_BIND        215..274
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   CONFLICT        118
FT                   /note="G -> K (in Ref. 2; AAY67941)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   283 AA;  31573 MW;  9AB5484989CFA9D9 CRC64;
     MGEHNLFNPG FVGQLVNINA RDAFYLSNFR ASGGQLAGLQ TLRLSRRDNV CSLPWNPSEA
     CSGYPQSHIS GPVTLNHTYN QSCDITRQED NKCFYSDSAC ATSGGGDNNS TNLISKEGAL
     DNSSVSITAE NGQNNLNGMD NGGSYSKYDC LTPAEQPIPN PRLCRSLESV SGCSFINEGA
     KTSSGITHSL TSPDIQTSVA ALNGGALWYP MHRQTRKKRK PYSKLQLNEL EGEFILNEFI
     TRQRRRELSD RLNLTDQQVK IWFQNRRMKK KRLLMREQAL SYF