ID   HXCDA_TAKRU             Reviewed;         306 AA.
AC   Q1KKV4;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Homeobox protein Hox-C13a;
GN   Name=hoxc13a;
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16636282; DOI=10.1073/pnas.0601492103;
RA   Lee A.P., Koh E.G.L., Tay A., Brenner S., Venkatesh B.;
RT   "Highly conserved syntenic blocks at the vertebrate Hox loci and conserved
RT   regulatory elements within and outside Hox gene clusters.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:6994-6999(2006).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
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DR   EMBL; DQ481667; ABF22440.1; -; Genomic_DNA.
DR   RefSeq; XP_003963119.1; XM_003963070.2.
DR   AlphaFoldDB; Q1KKV4; -.
DR   SMR; Q1KKV4; -.
DR   STRING; 31033.ENSTRUP00000010421; -.
DR   Ensembl; ENSTRUT00000010479; ENSTRUP00000010421; ENSTRUG00000004383.
DR   GeneID; 101079732; -.
DR   KEGG; tru:101079732; -.
DR   CTD; 58059; -.
DR   eggNOG; KOG0487; Eukaryota.
DR   GeneTree; ENSGT00940000161087; -.
DR   HOGENOM; CLU_059940_0_0_1; -.
DR   InParanoid; Q1KKV4; -.
DR   OMA; SKNNHMH; -.
DR   OrthoDB; 1190384at2759; -.
DR   TreeFam; TF330813; -.
DR   Proteomes; UP000005226; Chromosome 3.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR022067; HoxA13_N.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF12284; HoxA13_N; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..306
FT                   /note="Homeobox protein Hox-C13a"
FT                   /id="PRO_0000265993"
FT   DNA_BIND        236..295
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          68..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   306 AA;  34596 MW;  2989A1A626C01253 CRC64;
     MTTSLVLHPR WADTLMYVYE KSPNENNQNK SQTMEGLSGN CPATHCRDLM SHPALGRHSG
     TIATHQGSVY SDISSPDTGR QCPAPQTSSS ASLSYGYPFG NPYYGCRLSH SHNVNLQQKP
     CSYHPAEKYA EPSSALPTEE LSSRAKEFAF YPSFASSYQA VPGYLDVSVM PSISGHPEPR
     HDALIPMEGY QHWALSNGWD GQVYCSKEQT QSTHLWKSPF PDVVPLQPEV SSYRRGRKKR
     VPYTKLQLKE LEKEYAASKF ITKDKRRRIS AATNLSERQV TIWFQNRRVK EKKFISKSKS
     SHMHTT