ID   HXCDB_DANRE             Reviewed;         273 AA.
AC   Q6JIY4; Q9YGS8;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Homeobox protein Hox-C13b;
GN   Name=hoxc13b;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION
RP   PHENOTYPE.
RC   TISSUE=Embryo;
RX   PubMed=15385162; DOI=10.1016/j.ydbio.2004.07.018;
RA   Thummel R., Li L., Tanase C., Sarras M.P. Jr., Godwin A.R.;
RT   "Differences in expression pattern and function between zebrafish hoxc13
RT   orthologs: recruitment of Hoxc13b into an early embryonic role.";
RL   Dev. Biol. 274:318-333(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 201-273.
RX   PubMed=9831563; DOI=10.1126/science.282.5394.1711;
RA   Amores A., Force A., Yan Y.-L., Joly L., Amemiya C., Fritz A., Ho R.K.,
RA   Langeland J., Prince V.E., Wang Y.-L., Westerfield M., Ekker M.,
RA   Postlethwait J.H.;
RT   "Zebrafish hox clusters and vertebrate genome evolution.";
RL   Science 282:1711-1714(1998).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis (By similarity).
CC       Plays a role in early embryonic development. {ECO:0000250,
CC       ECO:0000269|PubMed:15385162}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
CC       Detected in every cell of early cleavage embryos through to gastrulae.
CC       From around 6 hours post-fertilization (hpf) through to early
CC       somitogenesis, expressed along the entire anterior to posterior length
CC       of the gastrula. At 19 hpf, expression is up-regulated in the
CC       developing tail bud and it becomes restricted to the tail bud by 24
CC       hpf. By 40 hpf, expression is further restricted within the tail bud,
CC       possibly to the developing vertebrae. No expression at 72 hpf.
CC       {ECO:0000269|PubMed:15385162}.
CC   -!- DISRUPTION PHENOTYPE: Morpholino knockdown of the protein results in a
CC       biphasic developmental delay characterized by a reduced body size with
CC       22-23 somites by 24 hpf; the first delay occurs before gastrulation and
CC       the second during late tail bud development.
CC       {ECO:0000269|PubMed:15385162}.
CC   -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
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DR   EMBL; AY452738; AAS16938.1; -; mRNA.
DR   EMBL; AF071262; AAD15955.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q6JIY4; -.
DR   SMR; Q6JIY4; -.
DR   STRING; 7955.ENSDARP00000104963; -.
DR   PaxDb; Q6JIY4; -.
DR   Ensembl; ENSDART00000182896; ENSDARP00000147440; ENSDARG00000113877.
DR   ZFIN; ZDB-GENE-000822-5; hoxc13b.
DR   eggNOG; KOG0487; Eukaryota.
DR   GeneTree; ENSGT00940000161087; -.
DR   HOGENOM; CLU_059940_0_0_1; -.
DR   InParanoid; Q6JIY4; -.
DR   OMA; GLACRCE; -.
DR   PhylomeDB; Q6JIY4; -.
DR   PRO; PR:Q6JIY4; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 11.
DR   Bgee; ENSDARG00000113877; Expressed in post-anal tail and 2 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0031101; P:fin regeneration; IMP:ZFIN.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR022067; HoxA13_N.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF12284; HoxA13_N; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..273
FT                   /note="Homeobox protein Hox-C13b"
FT                   /id="PRO_0000200200"
FT   DNA_BIND        201..260
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
SQ   SEQUENCE   273 AA;  30931 MW;  B924440ACC30B621 CRC64;
     MEGLSGNCPA SHCRDFISHP ALGRHSGSLA SHQGTVYPDI TTQDAGRQFP APQASSGTSL
     GYGYAFGSPY YGCRLSYSHN VNLQQKSYHP AEKYMETSGA LPAEELSSRS KEFAIYPSFA
     SSYQTVPGYL DVPVVPGISA HPESRHEALF PMDSYQHWAL SNGWDEQLYC SKEQTHFNHL
     WKSQFSDVVP HQAEMNGYRR GRKKRVPYTK IQLKELEKEY AASKFITKDR RRRISATTSL
     SERQVTIWFQ NRRVKEKKFV CKSSKSSTNM HSV