ID   HXD10_CHICK             Reviewed;          95 AA.
AC   P24341;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 2.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Homeobox protein Hox-D10;
DE   AltName: Full=Chox-4D;
DE   AltName: Full=Homeobox protein Hox-4.5;
DE            Short=Chox-4.5;
DE   Flags: Fragment;
GN   Name=HOXD10; Synonyms=CHOX-4.5;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1672266; DOI=10.1016/0092-8674(91)90274-3;
RA   Nohno T., Noji S., Koyama E., Ohyama K., Myokai F., Kuroiwa A., Saito T.,
RA   Taniguchi S.;
RT   "Involvement of the Chox-4 chicken homeobox genes in determination of
RT   anteroposterior axial polarity during limb development.";
RL   Cell 64:1197-1205(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 21-80.
RX   PubMed=1673231; DOI=10.1038/350585a0;
RA   Izpisua-Belmonte J.-C., Tickle C., Dolle P., Wolpert L., Duboule D.;
RT   "Expression of the homeobox Hox-4 genes and the specification of position
RT   in chick wing development.";
RL   Nature 350:585-589(1991).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DEVELOPMENTAL STAGE: Coordinately expressed in partially overlapping
CC       domains during wing development.
CC   -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA01132.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; D10287; BAA01132.1; ALT_INIT; Genomic_DNA.
DR   PIR; A37914; A37914.
DR   AlphaFoldDB; P24341; -.
DR   SMR; P24341; -.
DR   STRING; 9031.ENSGALP00000037896; -.
DR   VEuPathDB; HostDB:geneid_771246; -.
DR   eggNOG; KOG0487; Eukaryota.
DR   InParanoid; P24341; -.
DR   PhylomeDB; P24341; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR046333; HXA10/ABDB-like.
DR   PANTHER; PTHR45874; PTHR45874; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           <1..95
FT                   /note="Homeobox protein Hox-D10"
FT                   /id="PRO_0000200228"
FT   DNA_BIND        21..80
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   NON_TER         1
SQ   SEQUENCE   95 AA;  11597 MW;  FC147A016FF1B5F4 CRC64;
     FLIEEIKSDT PTSNWLTAKS GRKKRCPYTK HQTLELEKEF LFNMYLTRER RLEISKSVNL
     TDRQVKIWFQ NRRMKLKKMS RENRIRELTA NLTFS