ID   HXD10_HETFR             Reviewed;         336 AA.
AC   Q9IA14;
DT   11-JUL-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Homeobox protein Hox-D10;
GN   Name=HOXD10;
OS   Heterodontus francisci (Horn shark) (Cestracion francisci).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Elasmobranchii; Galeomorphii; Heterodontoidea; Heterodontiformes;
OC   Heterodontidae; Heterodontus.
OX   NCBI_TaxID=7792;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10677514; DOI=10.1073/pnas.030539697;
RA   Kim C.B., Amemiya C., Bailey W., Kawasaki K., Mezey J., Miller W.,
RA   Minoshima S., Shimizu N., Wagner G., Ruddle F.;
RT   "Hox cluster genomics in the horn shark, Heterodontus francisci.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:1655-1660(2000).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
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DR   EMBL; AF224263; AAF44634.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9IA14; -.
DR   SMR; Q9IA14; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR046333; HXA10/ABDB-like.
DR   PANTHER; PTHR45874; PTHR45874; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..336
FT                   /note="Homeobox protein Hox-D10"
FT                   /id="PRO_0000200230"
FT   DNA_BIND        262..321
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          193..217
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   336 AA;  38019 MW;  9C38BBAA8F420424 CRC64;
     MSCPNSSPAT NSFLVDSLIS ACRGDSFYST SSMYMPSSTD MGTYGMQTCG LLPTMTKRGE
     VNHQNMSISV HPYLSQVDGW ADPSRPCRIE QPVTPQMPTC SFPASVKEES TCCMYNSDKR
     AKLNPTAIPA YPRLVSENCS IENPEIPIPG YFRLCQAYPL EKSLDYNYAG EISSNVMPQS
     NLGLISKLQV SSQPPMERKI NEKPNAQEST KGIYVESPEP KPRLLEVSAT AEGAATSSEL
     SDNETKEEIK TPISNWLTAK SGRKKRCPYT KYQTLELEKE FLFNMYLTRE RRLEISKSVN
     LTDRQVKIWF QNRRMKLKKM NRETRIRELT TNLTFS