HXD10_MOUSE
ID HXD10_MOUSE Reviewed; 340 AA.
AC P28359; Q91WU9;
DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 2.
DT 03-AUG-2022, entry version 177.
DE RecName: Full=Homeobox protein Hox-D10;
DE AltName: Full=Homeobox protein Hox-4.5;
DE AltName: Full=Homeobox protein Hox-5.3;
GN Name=Hoxd10; Synonyms=Hox-4.5, Hoxd-10;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1348690; DOI=10.1002/j.1460-2075.1992.tb05190.x;
RA Renucci A.G.P., Zappavigna V., Zakany J., Izpisua-Belmonte J.-C.,
RA Buerki K., Douboule D.;
RT "Comparison of mouse and human HOX-4 complexes defines conserved sequences
RT involved in the regulation of Hox-4.4.";
RL EMBO J. 11:1459-1468(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Kidney, and Limb;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 266-325.
RX PubMed=2569970; DOI=10.1002/j.1460-2075.1989.tb03535.x;
RA Dolle P., Duboule D.;
RT "Two gene members of the murine HOX-5 complex show regional and cell-type
RT specific expression in developing limbs and gonads.";
RL EMBO J. 8:1507-1515(1989).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 266-325, AND DEVELOPMENTAL STAGE.
RX PubMed=2569969; DOI=10.1002/j.1460-2075.1989.tb03534.x;
RA Duboule D., Dolle P.;
RT "The structural and functional organization of the murine HOX gene family
RT resembles that of Drosophila homeotic genes.";
RL EMBO J. 8:1497-1505(1989).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-238 AND SER-239, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC -!- INTERACTION:
CC P28359; O88513: Gmnn; NbExp=2; IntAct=EBI-445929, EBI-445922;
CC P28359; P70323: Tbx1; NbExp=3; IntAct=EBI-445929, EBI-13635846;
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- DEVELOPMENTAL STAGE: Expressed in the developing limb buds. Expressed
CC in the posterior-most regions of the fetus. Strongly expressed in 12.5
CC day old fetuses in both spinal cord and pre-vertebral column with an
CC anterior boundary of expression lying at the level of the second or
CC third lumbar pre-vertebrae. {ECO:0000269|PubMed:2569969}.
CC -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
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DR EMBL; X62669; CAA44541.1; -; Genomic_DNA.
DR EMBL; BC013463; AAH13463.1; -; mRNA.
DR EMBL; BC048690; AAH48690.1; -; mRNA.
DR EMBL; X14715; CAB57814.1; -; Genomic_DNA.
DR CCDS; CCDS16141.1; -.
DR PIR; S20879; S20879.
DR RefSeq; NP_038582.2; NM_013554.5.
DR AlphaFoldDB; P28359; -.
DR SMR; P28359; -.
DR BioGRID; 200392; 10.
DR IntAct; P28359; 6.
DR STRING; 10090.ENSMUSP00000062412; -.
DR iPTMnet; P28359; -.
DR PhosphoSitePlus; P28359; -.
DR jPOST; P28359; -.
DR MaxQB; P28359; -.
DR PaxDb; P28359; -.
DR PRIDE; P28359; -.
DR ProteomicsDB; 267026; -.
DR Antibodypedia; 33906; 309 antibodies from 30 providers.
DR DNASU; 15430; -.
DR Ensembl; ENSMUST00000061745; ENSMUSP00000062412; ENSMUSG00000050368.
DR GeneID; 15430; -.
DR KEGG; mmu:15430; -.
DR UCSC; uc008kdx.3; mouse.
DR CTD; 3236; -.
DR MGI; MGI:96202; Hoxd10.
DR VEuPathDB; HostDB:ENSMUSG00000050368; -.
DR eggNOG; KOG0487; Eukaryota.
DR GeneTree; ENSGT00940000158266; -.
DR HOGENOM; CLU_057871_0_0_1; -.
DR InParanoid; P28359; -.
DR OMA; SYGMQTC; -.
DR OrthoDB; 976319at2759; -.
DR PhylomeDB; P28359; -.
DR TreeFam; TF317819; -.
DR BioGRID-ORCS; 15430; 2 hits in 74 CRISPR screens.
DR ChiTaRS; Hoxd10; mouse.
DR PRO; PR:P28359; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; P28359; protein.
DR Bgee; ENSMUSG00000050368; Expressed in uterus and 87 other tissues.
DR Genevisible; P28359; MM.
DR GO; GO:0036464; C:cytoplasmic ribonucleoprotein granule; ISO:MGI.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IDA:MGI.
DR GO; GO:0003677; F:DNA binding; IDA:MGI.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0008344; P:adult locomotory behavior; IGI:MGI.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IGI:MGI.
DR GO; GO:0030326; P:embryonic limb morphogenesis; IGI:MGI.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; IGI:MGI.
DR GO; GO:0035136; P:forelimb morphogenesis; IGI:MGI.
DR GO; GO:0035137; P:hindlimb morphogenesis; IGI:MGI.
DR GO; GO:0050905; P:neuromuscular process; IGI:MGI.
DR GO; GO:0048935; P:peripheral nervous system neuron development; IGI:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR GO; GO:0009954; P:proximal/distal pattern formation; IGI:MGI.
DR GO; GO:0010468; P:regulation of gene expression; IGI:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007338; P:single fertilization; IGI:MGI.
DR GO; GO:0007519; P:skeletal muscle tissue development; IGI:MGI.
DR GO; GO:0001501; P:skeletal system development; IMP:MGI.
DR GO; GO:0021520; P:spinal cord motor neuron cell fate specification; IGI:MGI.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR046333; HXA10/ABDB-like.
DR PANTHER; PTHR45874; PTHR45874; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Phosphoprotein;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..340
FT /note="Homeobox protein Hox-D10"
FT /id="PRO_0000200227"
FT DNA_BIND 266..325
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 185..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 195..215
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 238
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 239
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 184
FT /note="G -> A (in Ref. 1; CAA44541)"
FT /evidence="ECO:0000305"
FT CONFLICT 189
FT /note="Q -> E (in Ref. 1; CAA44541)"
FT /evidence="ECO:0000305"
FT CONFLICT 207
FT /note="G -> A (in Ref. 1; CAA44541)"
FT /evidence="ECO:0000305"
FT CONFLICT 268
FT /note="K -> E (in Ref. 1, 3 and 4)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 340 AA; 38328 MW; 974ABDB417F9F90D CRC64;
MSFPNSSPAA NTFLVDSLIS ACRSDSFYSS SASMYMPPPS ADMGTYGMQT CGLLPSLAKR
EVNHQNMGMN VHPYIPQVDS WTDPNRSCRI EQPVTQQVPT CSFTANIKEE SNCCMYSDKR
NKLISAEVPS YQRLVPESCP VENPEVPVPG YFRLSQTYAT GKTQEYNNSP EGSSTVMLQL
NPRGAAKPQL SAAQLQMEKK MNESASGQEP TKVSQVESPE AKGGLPEDRS CLAEVSVSSP
EVQEKESKEE IKSDTPTSNW LTAKSGRKKR CPYTKHQTLE LEKEFLFNMY LTRERRLEIS
KSVNLTDRQV KIWFQNRRMK LKKMSRENRI RELTANLTFS