HXD11_CHICK
ID HXD11_CHICK Reviewed; 280 AA.
AC P24342; Q90780;
DT 01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1993, sequence version 2.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Homeobox protein Hox-D11;
DE AltName: Full=Homeobox protein Hox-4.6;
DE Short=Chox-4.6;
DE Short=Ghox-4.6;
DE AltName: Full=Homeobox protein Hox-4E;
DE Short=Chox-4E;
GN Name=HOXD11; Synonyms=CHOX-4.6;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1347239; DOI=10.1002/aja.1001930112;
RA Rogina B., Coelho C.N., Kosher R.A., Upholt W.B.;
RT "The pattern of expression of the chicken homolog of HOX1I in the
RT developing limb suggests a possible role in the ectodermal inhibition of
RT chondrogenesis.";
RL Dev. Dyn. 193:92-101(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE OF 181-280.
RA Nohno T.;
RL Submitted (FEB-1992) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 208-268.
RX PubMed=1672266; DOI=10.1016/0092-8674(91)90274-3;
RA Nohno T., Noji S., Koyama E., Ohyama K., Myokai F., Kuroiwa A., Saito T.,
RA Taniguchi S.;
RT "Involvement of the Chox-4 chicken homeobox genes in determination of
RT anteroposterior axial polarity during limb development.";
RL Cell 64:1197-1205(1991).
RN [4]
RP NUCLEOTIDE SEQUENCE OF 208-267.
RX PubMed=1673231; DOI=10.1038/350585a0;
RA Izpisua-Belmonte J.-C., Tickle C., Dolle P., Wolpert L., Duboule D.;
RT "Expression of the homeobox Hox-4 genes and the specification of position
RT in chick wing development.";
RL Nature 350:585-589(1991).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- DEVELOPMENTAL STAGE: Coordinately expressed in partially overlapping
CC domains during wing development.
CC -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
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DR EMBL; M81249; AAA48822.1; -; mRNA.
DR EMBL; D10288; BAA01133.1; -; Genomic_DNA.
DR PIR; B37914; B37914.
DR RefSeq; NP_989951.1; NM_204620.1.
DR AlphaFoldDB; P24342; -.
DR SMR; P24342; -.
DR STRING; 9031.ENSGALP00000015069; -.
DR PaxDb; P24342; -.
DR Ensembl; ENSGALT00000059654; ENSGALP00000046110; ENSGALG00000039629.
DR GeneID; 395328; -.
DR KEGG; gga:395328; -.
DR CTD; 3237; -.
DR VEuPathDB; HostDB:geneid_395328; -.
DR eggNOG; KOG0487; Eukaryota.
DR GeneTree; ENSGT00940000161308; -.
DR HOGENOM; CLU_079662_0_0_1; -.
DR InParanoid; P24342; -.
DR OMA; YYSTDEI; -.
DR OrthoDB; 976319at2759; -.
DR PhylomeDB; P24342; -.
DR PRO; PR:P24342; -.
DR Proteomes; UP000000539; Chromosome 7.
DR Bgee; ENSGALG00000039629; Expressed in colon and 4 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR021918; DUF3528.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF12045; DUF3528; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..280
FT /note="Homeobox protein Hox-D11"
FT /id="PRO_0000200233"
FT DNA_BIND 208..267
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 135..211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..184
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 181..200
FT /note="VTTASGAASPPGEAVAEKSN -> SSSQPSAVVFCINQHFLSLI (in
FT Ref. 2)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 280 AA; 31923 MW; 8E0877450FD4B922 CRC64;
MTEFDDCSHG ASNMYLPGCA YYVSPSDFST KPSFLSQSSS CQMTFPYSSN LPHVQPVREV
AFREYGLERG KWQYRGSYAP YYSAEEVMHR DFLQPANRRT EMLFKTDPVC GHHGASPAAS
NFYGSVGRNG ILPQGFDQFY EPAPAPPYQQ HSEGEGDADK GELKPQHSAC SKAPSGQEKK
VTTASGAASP PGEAVAEKSN SSAVPQRSRK KRCPYTKYQI RELEREFFFN VYINKEKRLQ
LSRMLNLTDR QVKIWFQNRR MKEKKLNRDR LQYFTGNPLF