HXD11_MOUSE
ID HXD11_MOUSE Reviewed; 323 AA.
AC P23813;
DT 01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-1992, sequence version 2.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Homeobox protein Hox-D11;
DE AltName: Full=Homeobox protein Hox-4.6;
DE AltName: Full=Homeobox protein Hox-5.5;
GN Name=Hoxd11; Synonyms=Hox-4.6, Hoxd-11;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1676674; DOI=10.1002/j.1460-2075.1991.tb07764.x;
RA Izpisua-Belmonte J.-C., Falkenstein H., Dolle P., Renucci A., Duboule D.;
RT "Murine genes related to the Drosophila AbdB homeotic genes are
RT sequentially expressed during development of the posterior part of the
RT body.";
RL EMBO J. 10:2279-2289(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/Sv;
RX PubMed=7902810; DOI=10.1002/j.1460-2075.1993.tb06028.x;
RA Gerard M., Duboule D., Zakany J.;
RT "Structure and activity of regulatory elements involved in the activation
RT of the Hoxd-11 gene during late gastrulation.";
RL EMBO J. 12:3539-3550(1993).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/Sv; TISSUE=Liver;
RA Takada S., Cook M., Kramlauf R., McMahon A.P.;
RL Submitted (MAY-1991) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- DEVELOPMENTAL STAGE: Expressed during development of the posterior part
CC of the body.
CC -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA42943.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; X60761; CAA43173.1; -; Genomic_DNA.
DR EMBL; X60762; CAA43173.1; JOINED; Genomic_DNA.
DR EMBL; X71422; CAA50553.1; -; Genomic_DNA.
DR EMBL; X60395; CAA42943.1; ALT_INIT; Genomic_DNA.
DR PIR; S16318; S16318.
DR RefSeq; NP_032299.1; NM_008273.2.
DR AlphaFoldDB; P23813; -.
DR SMR; P23813; -.
DR STRING; 10090.ENSMUSP00000122582; -.
DR iPTMnet; P23813; -.
DR PhosphoSitePlus; P23813; -.
DR PaxDb; P23813; -.
DR PRIDE; P23813; -.
DR ProteomicsDB; 273330; -.
DR DNASU; 15431; -.
DR GeneID; 15431; -.
DR KEGG; mmu:15431; -.
DR CTD; 3237; -.
DR MGI; MGI:96203; Hoxd11.
DR eggNOG; KOG0487; Eukaryota.
DR InParanoid; P23813; -.
DR OrthoDB; 976319at2759; -.
DR BioGRID-ORCS; 15431; 0 hits in 74 CRISPR screens.
DR PRO; PR:P23813; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; P23813; protein.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IGI:MGI.
DR GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; IGI:MGI.
DR GO; GO:0060351; P:cartilage development involved in endochondral bone morphogenesis; IGI:MGI.
DR GO; GO:0048468; P:cell development; IGI:MGI.
DR GO; GO:0002063; P:chondrocyte development; IGI:MGI.
DR GO; GO:0002062; P:chondrocyte differentiation; IGI:MGI.
DR GO; GO:0048589; P:developmental growth; IGI:MGI.
DR GO; GO:0009953; P:dorsal/ventral pattern formation; IGI:MGI.
DR GO; GO:0042733; P:embryonic digit morphogenesis; IGI:MGI.
DR GO; GO:0035115; P:embryonic forelimb morphogenesis; IGI:MGI.
DR GO; GO:0030326; P:embryonic limb morphogenesis; IGI:MGI.
DR GO; GO:0060272; P:embryonic skeletal joint morphogenesis; IGI:MGI.
DR GO; GO:0001656; P:metanephros development; IGI:MGI.
DR GO; GO:0001759; P:organ induction; IGI:MGI.
DR GO; GO:0007389; P:pattern specification process; IGI:MGI.
DR GO; GO:1902761; P:positive regulation of chondrocyte development; IGI:MGI.
DR GO; GO:0032332; P:positive regulation of chondrocyte differentiation; IGI:MGI.
DR GO; GO:0009954; P:proximal/distal pattern formation; IGI:MGI.
DR GO; GO:0032330; P:regulation of chondrocyte differentiation; IGI:MGI.
DR GO; GO:0010468; P:regulation of gene expression; IGI:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007338; P:single fertilization; IGI:MGI.
DR GO; GO:0001501; P:skeletal system development; IMP:MGI.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR021918; DUF3528.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF12045; DUF3528; 2.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..323
FT /note="Homeobox protein Hox-D11"
FT /id="PRO_0000200232"
FT DNA_BIND 251..310
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 164..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..193
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 323 AA; 33546 MW; B003D1347F5FE771 CRC64;
MYLPGCAYYV APSDFASKPS FLSQPSSCQM TFPYSSNLAP HVQPVREVAF RDYGLERAKW
PYRGGGGGGA GGGGGGGPGG GGGGSGGYAP YYAAAAAAAA AAAAAEEAAM QRDLLPPAGR
RPDVLFKAPE PVCGAPGPPH GPAAAASNFY SAVGRNGILP QGFDQFYEAA PGPPFAGPQP
QPAPAPPQPE GAADKGDPKP GAGGGGGSPC AKATPGPEPK GAAEGGGGEG EGPPGEAGAE
KSGGTVAPQR SRKKRCPYTK YQIRELEREF FFNVYINKEK RLQLSRMLNL TDRQVKIWFQ
NRRMKEKKLN RDRLQYFTGN PLF
