ID   HXD11_NOTVI             Reviewed;         277 AA.
AC   P31263;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Homeobox protein Hox-D11;
DE   AltName: Full=NvHox-2;
GN   Name=HOXD11; Synonyms=NVHOX2;
OS   Notophthalmus viridescens (Eastern newt) (Triturus viridescens).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Caudata; Salamandroidea; Salamandridae; Pleurodelinae;
OC   Notophthalmus.
OX   NCBI_TaxID=8316;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1680049; DOI=10.1242/dev.111.2.489;
RA   Brown R., Brockes J.P.;
RT   "Identification and expression of a regeneration-specific homeobox gene in
RT   the newt limb blastema.";
RL   Development 111:489-496(1991).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
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DR   EMBL; X57674; -; NOT_ANNOTATED_CDS; mRNA.
DR   PIR; A43783; A43783.
DR   AlphaFoldDB; P31263; -.
DR   SMR; P31263; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR021918; DUF3528.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF12045; DUF3528; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..277
FT                   /note="Homeobox protein Hox-D11"
FT                   /id="PRO_0000200236"
FT   DNA_BIND        205..264
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          143..209
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        169..183
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        191..206
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   277 AA;  31783 MW;  EC805399F6BA2B9F CRC64;
     MTEFDGCTNG ATNMYLPGCA YYVSPSEFST KTSFLSQGSS CPVTFPYSSN LPHVQPVREM
     AFREYGWRRS KWQYRGSYPS YYPSEEVVAR DFIQPSNRRS DVLFKADPLC AHHGTPSAAS
     NLYSTVGRNG VLPQEFDQFY EASQPTSVPP EHVGSLDKTG SKTQEVPPKI THSPDKKMGA
     EGRADSPSGE VAADKSNSSA TPQRSRKKRC PYTKYQIREL EREFFFNVYI NKEKRLQLSR
     MLNLTDRQVK IWFQNRRMKE KKLNRDRLQY FTGNPLF