ID   HXD12_CARPS             Reviewed;         270 AA.
AC   Q5EU40;
DT   24-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Homeobox protein Hox-D12;
GN   Name=HOXD12;
OS   Carollia perspicillata (Seba's short-tailed bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Phyllostomidae;
OC   Carolliinae; Carollia.
OX   NCBI_TaxID=40233;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=15733311; DOI=10.1111/j.1525-142x.2005.05015.x;
RA   Chen C.-H., Cretekos C.J., Rasweiler J.J. IV, Behringer R.R.;
RT   "Hoxd13 expression in the developing limbs of the short-tailed fruit bat,
RT   Carollia perspicillata.";
RL   Evol. Dev. 7:130-141(2005).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
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DR   EMBL; AY744676; AAW66481.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q5EU40; -.
DR   SMR; Q5EU40; -.
DR   PRIDE; Q5EU40; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..270
FT                   /note="Homeobox protein Hox-D12"
FT                   /id="PRO_0000200237"
FT   DNA_BIND        202..261
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          103..127
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   270 AA;  29149 MW;  633F0166DE38C559 CRC64;
     MCERSLYRAG YVGSLLNLQS PDSFYFSNLR PNGGQLAALP PISYPRGALP WATTPASCAP
     AQPAGATAFG SFSQPYLAGS GPLGLQPLGA KDRPEEQAKF YTPDVAAGPE ERGRSRPPFA
     PESSLVPGTA GLKSTKYDYA GVGRAAPGSA ALLEGTPCAA GFKDDAKGPL NLNMTVQAAG
     VASCLRPSLP DGLPWGAAPG RARKKRKPYT KQQIAELENE FLLNEFINRQ KRKELSNRLN
     LSDQQVKIWF QNRRMKKKRV VLREQALALY