HXD12_CHICK
ID HXD12_CHICK Reviewed; 266 AA.
AC P24343;
DT 01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1993, sequence version 2.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Homeobox protein Hox-D12;
DE AltName: Full=Homeobox protein Hox-4.7;
DE Short=Chox-4.7;
DE Short=Ghox-4.7;
DE AltName: Full=Homeobox protein Hox-4F;
DE Short=Chox-4F;
GN Name=HOXD12; Synonyms=CHOX-4.7;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1682126; DOI=10.1242/dev.112.3.791;
RA Mackem S., Mahon K.A.;
RT "Ghox 4.7: a chick homeobox gene expressed primarily in limb buds with
RT limb-type differences in expression.";
RL Development 112:791-806(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 196-258.
RX PubMed=1672266; DOI=10.1016/0092-8674(91)90274-3;
RA Nohno T., Noji S., Koyama E., Ohyama K., Myokai F., Kuroiwa A., Saito T.,
RA Taniguchi S.;
RT "Involvement of the Chox-4 chicken homeobox genes in determination of
RT anteroposterior axial polarity during limb development.";
RL Cell 64:1197-1205(1991).
RN [3]
RP NUCLEOTIDE SEQUENCE OF 198-257.
RX PubMed=1673231; DOI=10.1038/350585a0;
RA Izpisua-Belmonte J.-C., Tickle C., Dolle P., Wolpert L., Duboule D.;
RT "Expression of the homeobox Hox-4 genes and the specification of position
RT in chick wing development.";
RL Nature 350:585-589(1991).
RN [4]
RP INTERACTION WITH MAF AND MAFB.
RX PubMed=11036080; DOI=10.1074/jbc.m007643200;
RA Kataoka K., Yoshitomo-Nakagawa K., Shioda S., Nishizawa M.;
RT "A set of Hox proteins interact with the Maf oncoprotein to inhibit its DNA
RT binding, transactivation, and transforming activities.";
RL J. Biol. Chem. 276:819-826(2001).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC -!- SUBUNIT: Interacts with MAF and MAFB. {ECO:0000269|PubMed:11036080}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Expressed primarily in limb buds.
CC -!- DEVELOPMENTAL STAGE: Coordinately expressed in partially overlapping
CC domains during wing development.
CC -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA01134.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; X62019; CAA43974.1; -; mRNA.
DR EMBL; D10289; BAA01134.1; ALT_INIT; Genomic_DNA.
DR PIR; A45186; A45186.
DR PIR; C37914; C37914.
DR PIR; S14800; S14800.
DR RefSeq; NP_990580.1; NM_205249.1.
DR AlphaFoldDB; P24343; -.
DR SMR; P24343; -.
DR MINT; P24343; -.
DR STRING; 9031.ENSGALP00000015070; -.
DR PaxDb; P24343; -.
DR Ensembl; ENSGALT00000087671; ENSGALP00000062834; ENSGALG00000009274.
DR GeneID; 396178; -.
DR KEGG; gga:396178; -.
DR CTD; 3238; -.
DR VEuPathDB; HostDB:geneid_396178; -.
DR eggNOG; KOG0487; Eukaryota.
DR GeneTree; ENSGT00940000159938; -.
DR HOGENOM; CLU_087968_1_0_1; -.
DR InParanoid; P24343; -.
DR OMA; FAQGAPW; -.
DR OrthoDB; 1154178at2759; -.
DR PhylomeDB; P24343; -.
DR TreeFam; TF351604; -.
DR PRO; PR:P24343; -.
DR Proteomes; UP000000539; Chromosome 7.
DR Bgee; ENSGALG00000009274; Expressed in colon.
DR ExpressionAtlas; P24343; baseline.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0042733; P:embryonic digit morphogenesis; IEA:Ensembl.
DR GO; GO:0007389; P:pattern specification process; IEA:Ensembl.
DR GO; GO:0001501; P:skeletal system development; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..266
FT /note="Homeobox protein Hox-D12"
FT /id="PRO_0000200240"
FT DNA_BIND 198..257
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT CONFLICT 198
FT /note="S -> R (in Ref. 3)"
FT /evidence="ECO:0000305"
FT CONFLICT 219
FT /note="L -> V (in Ref. 3)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 266 AA; 30014 MW; AD2D45FD24AC6D73 CRC64;
MCDRSLYRSG YVGSLLNLQS PDSFYFPNLR ANGSQLAALP TISYPRSSIP WTCPSPCAAQ
PQGHAFGGAA QPYLPGSVPI SISSNSNKEC LEENSKYYAH DASSKQEERC RQRQSFANDP
TITHAANLKP AKYDHSSLPR SLHGSAALFE VNSCTSSLKE DIKNSVNLNL TVQPAAVQSC
LRPSVQDGLP WCPTQGRSRK KRKPYTKQQI AELENEFLLN EFINRQKRKE LSNRLNLSDQ
QVKIWFQNRR MKKKRVVMRE QALSMY
