HXD12_HETFR
ID HXD12_HETFR Reviewed; 272 AA.
AC Q9IA16;
DT 11-JUL-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=Homeobox protein Hox-D12;
GN Name=HOXD12;
OS Heterodontus francisci (Horn shark) (Cestracion francisci).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Heterodontoidea; Heterodontiformes;
OC Heterodontidae; Heterodontus.
OX NCBI_TaxID=7792;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10677514; DOI=10.1073/pnas.030539697;
RA Kim C.B., Amemiya C., Bailey W., Kawasaki K., Mezey J., Miller W.,
RA Minoshima S., Shimizu N., Wagner G., Ruddle F.;
RT "Hox cluster genomics in the horn shark, Heterodontus francisci.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:1655-1660(2000).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF224263; AAF44636.1; -; Genomic_DNA.
DR AlphaFoldDB; Q9IA16; -.
DR SMR; Q9IA16; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Transcription;
KW Transcription regulation.
FT CHAIN 1..272
FT /note="Homeobox protein Hox-D12"
FT /id="PRO_0000200242"
FT DNA_BIND 204..263
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
SQ SEQUENCE 272 AA; 30902 MW; F913F5BE7CC06B45 CRC64;
MCEHNLLNSG YVGSLLNFTS PEPFYFANLR PNGTQLATLS PALSYTRRDV CSLPWTSSPC
ASPPQSRAFS GYSQSYLSNS VSISINRHVS DKAAAGEEPN KYYFQDSSRK VEERCRHNQS
YPSDASIPSS VNINPAKYEY PNVETSLHGS SLHNQGFELN SNSPTVNDGI KQSVSLSMSL
QSSVTPVCNR SSDGLPWCPT QVRSRRKRKP YTKQQIAELE NEFLANEFIN RQKRKELSDR
LNLSDQQVKI WFQNRRMKKK RLVMREQTLS LF