HXD12_MOUSE
ID HXD12_MOUSE Reviewed; 268 AA.
AC P23812; Q8BSN0;
DT 01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT 22-SEP-2009, sequence version 2.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Homeobox protein Hox-D12;
DE AltName: Full=Homeobox protein Hox-4.7;
DE AltName: Full=Homeobox protein Hox-5.6;
GN Name=Hoxd12; Synonyms=Hox-4.7, Hoxd-12;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1676674; DOI=10.1002/j.1460-2075.1991.tb07764.x;
RA Izpisua-Belmonte J.-C., Falkenstein H., Dolle P., Renucci A., Duboule D.;
RT "Murine genes related to the Drosophila AbdB homeotic genes are
RT sequentially expressed during development of the posterior part of the
RT body.";
RL EMBO J. 10:2279-2289(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Forelimb;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- DEVELOPMENTAL STAGE: Expressed during development of the posterior part
CC of the body.
CC -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA41654.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; X58849; CAA41654.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AK031206; BAC27299.1; -; mRNA.
DR EMBL; AL928644; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466519; EDL27169.1; -; Genomic_DNA.
DR EMBL; BC145656; AAI45657.1; -; mRNA.
DR CCDS; CCDS38147.1; -.
DR PIR; S16317; S16317.
DR RefSeq; NP_032300.2; NM_008274.3.
DR AlphaFoldDB; P23812; -.
DR SMR; P23812; -.
DR BioGRID; 200394; 9.
DR IntAct; P23812; 10.
DR STRING; 10090.ENSMUSP00000001878; -.
DR iPTMnet; P23812; -.
DR PhosphoSitePlus; P23812; -.
DR MaxQB; P23812; -.
DR PaxDb; P23812; -.
DR PRIDE; P23812; -.
DR Antibodypedia; 10810; 250 antibodies from 32 providers.
DR DNASU; 15432; -.
DR Ensembl; ENSMUST00000001878; ENSMUSP00000001878; ENSMUSG00000001823.
DR GeneID; 15432; -.
DR KEGG; mmu:15432; -.
DR UCSC; uc008kdv.2; mouse.
DR CTD; 3238; -.
DR MGI; MGI:96204; Hoxd12.
DR VEuPathDB; HostDB:ENSMUSG00000001823; -.
DR eggNOG; KOG0487; Eukaryota.
DR GeneTree; ENSGT00940000159938; -.
DR HOGENOM; CLU_087968_0_0_1; -.
DR InParanoid; P23812; -.
DR OMA; FAQGAPW; -.
DR OrthoDB; 1154178at2759; -.
DR PhylomeDB; P23812; -.
DR TreeFam; TF351604; -.
DR BioGRID-ORCS; 15432; 3 hits in 72 CRISPR screens.
DR PRO; PR:P23812; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; P23812; protein.
DR Bgee; ENSMUSG00000001823; Expressed in undifferentiated genital tubercle and 76 other tissues.
DR Genevisible; P23812; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IDA:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0042733; P:embryonic digit morphogenesis; IGI:MGI.
DR GO; GO:0007389; P:pattern specification process; IGI:MGI.
DR GO; GO:0001501; P:skeletal system development; IMP:MGI.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..268
FT /note="Homeobox protein Hox-D12"
FT /id="PRO_0000200239"
FT DNA_BIND 200..259
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 102..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 268 AA; 29198 MW; 5EA04C2B59336AC4 CRC64;
MCERSLYRAG YVGSLLNLQS PDSFYFSNLR ANGSQLAALP PISYPRSALP WATTPASCTP
AQPATASAFG GFSQPYLTGS GPIGLQSPGA KDGPEDQVKF YTPDAPTASE ERSRTRPPFA
PESSLVHSAL KGTKYDYAGV GRTAPGSATL LQGAPCASSF KEDTKGPLNL NMAVQVAGVA
SCLRSSLPDG LPWGAAPGRA RKKRKPYTKQ QIAELENEFL VNEFINRQKR KELSNRLNLS
DQQVKIWFQN RRMKKKRVVQ REQALALY
