ID   HXD13_CARPS             Reviewed;         333 AA.
AC   Q5EU41;
DT   24-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Homeobox protein Hox-D13;
GN   Name=HOXD13;
OS   Carollia perspicillata (Seba's short-tailed bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Phyllostomidae;
OC   Carolliinae; Carollia.
OX   NCBI_TaxID=40233;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=15733311; DOI=10.1111/j.1525-142x.2005.05015.x;
RA   Chen C.-H., Cretekos C.J., Rasweiler J.J. IV, Behringer R.R.;
RT   "Hoxd13 expression in the developing limbs of the short-tailed fruit bat,
RT   Carollia perspicillata.";
RL   Evol. Dev. 7:130-141(2005).
CC   -!- FUNCTION: Sequence-specific transcription factor that binds gene
CC       promoters and activates their transcription. Part of a developmental
CC       regulatory system that provides cells with specific positional
CC       identities on the anterior-posterior axis.
CC       {ECO:0000250|UniProtKB:P24344}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P70217}.
CC   -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
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DR   EMBL; AY744676; AAW66480.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q5EU41; -.
DR   SMR; Q5EU41; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISS:UniProtKB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR022067; HoxA13_N.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF12284; HoxA13_N; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..333
FT                   /note="Homeobox protein Hox-D13"
FT                   /id="PRO_0000200243"
FT   DNA_BIND        266..325
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   333 AA;  35042 MW;  EB8080AB608224AC CRC64;
     MDGLRTDGGA AGAAPASSSS SSSVAAAAPG QCRGFLSAPV FAGTHSGRAA AAAAAAAAAA
     AAASGFAYPG TSERAGSASS SSSSAVVAAR PEAPSAKECP APGTAATAPP GAPALGYGYH
     FGNGYYSCRM SHGVGLQQNA LKSSPHSSLG GFPVEKYMDV SGLASSSVPA NEVPARAKEV
     SFYQGYTSPY QHVPGYIDMV STFGSGEPRH EAYISMEGYQ SWTLANGWNS QVYCAKDQPQ
     GSHFWKSSFP GDVALNQPDM CVYRRGRKKR VPYTKLQLKE LENEYAINKF INKDKRRRIS
     AATNLSERQV TIWFQNRRVK DKKIVSKLKD TVS