ID   HXD13_CHICK             Reviewed;         301 AA.
AC   P24344; Q90781;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 3.
DT   03-AUG-2022, entry version 130.
DE   RecName: Full=Homeobox protein Hox-D13;
DE   AltName: Full=Homeobox protein Hox-4.8;
DE            Short=Chox-4.8;
DE   AltName: Full=Homeobox protein Hox-4G;
DE            Short=Chox-4G;
GN   Name=HOXD13; Synonyms=CHOX-4.8;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8096637; DOI=10.1093/nar/21.5.1316;
RA   Rogina B., Upholt W.B.;
RT   "Cloning of full coding chicken cDNAs for the homeobox-containing gene
RT   Hoxd-13.";
RL   Nucleic Acids Res. 21:1316-1316(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE OF 208-301.
RA   Nohno T.;
RL   Submitted (FEB-1992) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 234-301, AND FUNCTION.
RX   PubMed=1672266; DOI=10.1016/0092-8674(91)90274-3;
RA   Nohno T., Noji S., Koyama E., Ohyama K., Myokai F., Kuroiwa A., Saito T.,
RA   Taniguchi S.;
RT   "Involvement of the Chox-4 chicken homeobox genes in determination of
RT   anteroposterior axial polarity during limb development.";
RL   Cell 64:1197-1205(1991).
RN   [4]
RP   NUCLEOTIDE SEQUENCE OF 234-293.
RX   PubMed=1673231; DOI=10.1038/350585a0;
RA   Izpisua-Belmonte J.-C., Tickle C., Dolle P., Wolpert L., Duboule D.;
RT   "Expression of the homeobox Hox-4 genes and the specification of position
RT   in chick wing development.";
RL   Nature 350:585-589(1991).
CC   -!- FUNCTION: Sequence-specific transcription factor that binds gene
CC       promoters and activates their transcription (By similarity). Part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis (PubMed:1672266).
CC       {ECO:0000250|UniProtKB:P70217, ECO:0000269|PubMed:1672266}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P70217}.
CC   -!- DEVELOPMENTAL STAGE: Coordinately expressed in partially overlapping
CC       domains during wing development.
CC   -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
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DR   EMBL; L09550; AAA48824.1; -; mRNA.
DR   EMBL; D10290; BAA01135.1; -; Genomic_DNA.
DR   PIR; S35526; S35526.
DR   RefSeq; NP_990765.1; NM_205434.1.
DR   AlphaFoldDB; P24344; -.
DR   SMR; P24344; -.
DR   STRING; 9031.ENSGALP00000015076; -.
DR   PaxDb; P24344; -.
DR   GeneID; 396415; -.
DR   KEGG; gga:396415; -.
DR   CTD; 3239; -.
DR   VEuPathDB; HostDB:geneid_396415; -.
DR   eggNOG; KOG0487; Eukaryota.
DR   InParanoid; P24344; -.
DR   OrthoDB; 1190384at2759; -.
DR   PhylomeDB; P24344; -.
DR   PRO; PR:P24344; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISS:UniProtKB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR022067; HoxA13_N.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF12284; HoxA13_N; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..301
FT                   /note="Homeobox protein Hox-D13"
FT                   /id="PRO_0000200246"
FT   DNA_BIND        234..293
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          55..75
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        208..218
FT                   /note="QSSHFWKSSFP -> NSNFSRRVFSL (in Ref. 2)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   301 AA;  32373 MW;  E598FD4E14AA6BCA CRC64;
     MDGLRGDSSG GGGGGGTPGQ CRNFLSSPVF GAAHTGRAAA AAAAAASGFA YAGGGERSGA
     AARPDPPAKD CPGSGAPPAA PALGYGYHFG NGYYSCRMSN GVGIQQNALK SPPHASIGGF
     PVEKYMDVSS LTSTSVPANE VSTRAKEVSS YQGYTNPYQH VPGYIDMVST FGSGEPRHET
     YISMEGYQSW TLANGWNGQV YCAKDQTQSS HFWKSSFPGD VALNQPEMCV YRRGRKKRVP
     YTKLQLKELE NEYAINKFIN KDKRRRISAA TNLSERQVTI WFQNRRVKDK KIVSKLKDNV
     S