HXD13_HETFR
ID HXD13_HETFR Reviewed; 284 AA.
AC Q9IA17;
DT 11-JUL-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 89.
DE RecName: Full=Homeobox protein Hox-D13;
GN Name=HOXD13;
OS Heterodontus francisci (Horn shark) (Cestracion francisci).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Heterodontoidea; Heterodontiformes;
OC Heterodontidae; Heterodontus.
OX NCBI_TaxID=7792;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10677514; DOI=10.1073/pnas.030539697;
RA Kim C.B., Amemiya C., Bailey W., Kawasaki K., Mezey J., Miller W.,
RA Minoshima S., Shimizu N., Wagner G., Ruddle F.;
RT "Hox cluster genomics in the horn shark, Heterodontus francisci.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:1655-1660(2000).
CC -!- FUNCTION: Sequence-specific transcription factor that binds gene
CC promoters and activates their transcription. Part of a developmental
CC regulatory system that provides cells with specific positional
CC identities on the anterior-posterior axis.
CC {ECO:0000250|UniProtKB:P35453}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P70217}.
CC -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
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DR EMBL; AF224263; AAF44637.1; -; Genomic_DNA.
DR AlphaFoldDB; Q9IA17; -.
DR SMR; Q9IA17; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISS:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR022067; HoxA13_N.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF12284; HoxA13_N; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Transcription;
KW Transcription regulation.
FT CHAIN 1..284
FT /note="Homeobox protein Hox-D13"
FT /id="PRO_0000200248"
FT DNA_BIND 217..276
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
SQ SEQUENCE 284 AA; 31871 MW; D7DDDE38936FACB1 CRC64;
MEGLGGNVPS NQCRNFLSPS AFGAHHNSLS SGPAYTVGDR THSVISESAK QCSPCPAPTS
PPNPAISYGY HFGSSYYSCR NVGIQQTGLK SGAHASLAGY PVDKYMDVSS LTNTPVPTDE
VSARAKEFAF YQSYPNPYQR VSGYLDVPVV PTISGHGEPR HEALISMEGY QPWTFANSWN
GQVYCPKDQT QTPHFWKSPL SGDVMHNQTD INIYRRGRKK RVPYTKTQLK ELEREYATNK
FITKEKRRRI STATNLTERQ VTIWFQNRRV KEKKVVSKVK ENIP