HXD1_MOUSE
ID HXD1_MOUSE Reviewed; 328 AA.
AC Q01822; Q0VBQ9;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 16-OCT-2013, sequence version 2.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Homeobox protein Hox-D1;
DE AltName: Full=Homeobox protein Hox-4.9;
GN Name=Hoxd1; Synonyms=Hox-4.9, Hoxd-1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=ICR;
RX PubMed=1356009; DOI=10.1016/0925-4773(92)90038-l;
RA Frohman M.A., Martin G.R.;
RT "Isolation and analysis of embryonic expression of Hox-4.9, a member of the
RT murine labial-like gene family.";
RL Mech. Dev. 38:55-67(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 219-328.
RC STRAIN=ICR X Swiss Webster; TISSUE=Liver;
RX PubMed=1348361; DOI=10.1073/pnas.89.7.2883;
RA Nazarali A., Kim Y., Nirenberg M.;
RT "Hox-1.11 and Hox-4.9 homeobox genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 89:2883-2887(1992).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis. Acts on the
CC anterior body structures.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- DEVELOPMENTAL STAGE: Is first detected at the end of the late streak
CC stage in presumptive lateral and extraembryonic mesoderm. During early
CC neurogenesis, it is detected solely in lateral mesoderm. By late
CC neurogenesis and through mid-gestation, it is found in a restricted
CC region of presumed trunk neural crest and the dermatome.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. Labial subfamily.
CC {ECO:0000305}.
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DR EMBL; X60034; CAA42637.1; -; mRNA.
DR EMBL; AL928733; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466519; EDL27181.1; -; Genomic_DNA.
DR EMBL; BC120537; AAI20538.1; -; mRNA.
DR EMBL; BC120539; AAI20540.1; -; mRNA.
DR EMBL; M87802; AAA37853.1; -; Genomic_DNA.
DR CCDS; CCDS16147.1; -.
DR PIR; A56553; A56553.
DR RefSeq; NP_034597.2; NM_010467.2.
DR AlphaFoldDB; Q01822; -.
DR SMR; Q01822; -.
DR BioGRID; 200391; 1.
DR IntAct; Q01822; 1.
DR STRING; 10090.ENSMUSP00000043078; -.
DR PhosphoSitePlus; Q01822; -.
DR PaxDb; Q01822; -.
DR PRIDE; Q01822; -.
DR Antibodypedia; 33916; 177 antibodies from 21 providers.
DR DNASU; 15429; -.
DR Ensembl; ENSMUST00000047793; ENSMUSP00000043078; ENSMUSG00000042448.
DR GeneID; 15429; -.
DR KEGG; mmu:15429; -.
DR UCSC; uc008kei.1; mouse.
DR CTD; 3231; -.
DR MGI; MGI:96201; Hoxd1.
DR VEuPathDB; HostDB:ENSMUSG00000042448; -.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000161892; -.
DR HOGENOM; CLU_058839_0_0_1; -.
DR InParanoid; Q01822; -.
DR OMA; MSSYLEY; -.
DR OrthoDB; 1216870at2759; -.
DR PhylomeDB; Q01822; -.
DR TreeFam; TF317730; -.
DR BioGRID-ORCS; 15429; 1 hit in 76 CRISPR screens.
DR PRO; PR:Q01822; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q01822; protein.
DR Bgee; ENSMUSG00000042448; Expressed in lumbar dorsal root ganglion and 69 other tissues.
DR Genevisible; Q01822; MM.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0048706; P:embryonic skeletal system development; IMP:MGI.
DR GO; GO:0030182; P:neuron differentiation; IMP:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0019233; P:sensory perception of pain; IMP:MGI.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR046327; HXA1/B1/D1.
DR PANTHER; PTHR45946; PTHR45946; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..328
FT /note="Homeobox protein Hox-D1"
FT /id="PRO_0000200202"
FT DNA_BIND 229..288
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 304..328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 204..209
FT /note="Antp-type hexapeptide"
FT CONFLICT 25
FT /note="G -> A (in Ref. 1; CAA42637)"
FT /evidence="ECO:0000305"
FT CONFLICT 32
FT /note="Missing (in Ref. 1; CAA42637)"
FT /evidence="ECO:0000305"
FT CONFLICT 48
FT /note="S -> N (in Ref. 1; CAA42637)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 328 AA; 34180 MW; 3452480CACED2FF7 CRC64;
MSSYLEYVSC AAGGGSGGVG GDVLGFAPKF CRADARPVAL QPAFPLGSGD GAFVSCLPLA
TARPTPSPPA GPAQSPVPQP AAPRYAPCTL EGAYERGAAP ASAAEYGFLG SGPAFDFPGA
LGRAADEGGA HVHYATSAVF SGGGSFLLSG QVDFAAFGEP GPFPACLKEP ADGHPGPFQT
VSPAPGACPK PASPTSSLPA AHSTFEWMKV KRNAPKKSKL SEYGATSPPS AIRTNFSTKQ
LTELEKEFHF NKYLTRARRI EIANCLQLND TQVKIWFQNR RMKQKKRERE GLLATAASVA
SIKLPRSETS PIKSGRNLGS PSQAQEPS
