HXD1_XENLA
ID HXD1_XENLA Reviewed; 300 AA.
AC Q08820; Q3KQ36; Q91767; Q91772;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 04-NOV-2008, sequence version 3.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Homeobox protein Hox-D1;
DE AltName: Full=Hox.lab1;
DE AltName: Full=Labial protein;
DE Short=Xlab;
GN Name=hoxd1; Synonyms=lab;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC TISSUE=Dorsal lip;
RX PubMed=1677215; DOI=10.1126/science.1677215;
RA Blumberg B., Wright C.V.E., De Robertis E.M., Cho K.W.Y.;
RT "Organizer-specific homeobox genes in Xenopus laevis embryos.";
RL Science 253:194-196(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Gastrula;
RA Kolm P.J., Frey J., Sive H.L.;
RL Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Neurula;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 75-300.
RX PubMed=1678362; DOI=10.1101/gad.5.8.1321;
RA Sive H.L., Cheng P.F.;
RT "Retinoic acid perturbs the expression of Xhox.lab genes and alters
RT mesodermal determination in Xenopus laevis.";
RL Genes Dev. 5:1321-1332(1991).
RN [5]
RP FUNCTION.
RX PubMed=15196951; DOI=10.1016/j.ydbio.2004.02.029;
RA Dibner C., Elias S., Ofir R., Souopgui J., Kolm P.J., Sive H.L., Pieler T.,
RA Frank D.;
RT "The Meis3 protein and retinoid signaling interact to pattern the Xenopus
RT hindbrain.";
RL Dev. Biol. 271:75-86(2004).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis. Acts on the
CC anterior body structures. Acts downstream of meis3 to pattern the
CC hindbrain. {ECO:0000269|PubMed:15196951}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Expression is abundant in the gastrula dorsal lip.
CC {ECO:0000269|PubMed:1677215}.
CC -!- DEVELOPMENTAL STAGE: First detected at stage 10.5 and peaks at mid-
CC gastrula (stage 11.5). {ECO:0000269|PubMed:1677215}.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. Labial subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA49745.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=CAA43980.1; Type=Miscellaneous discrepancy; Note=Sequence of unknown origin at C-terminus.; Evidence={ECO:0000305};
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DR EMBL; M63873; AAA49745.1; ALT_FRAME; mRNA.
DR EMBL; L25857; AAA03480.1; -; mRNA.
DR EMBL; BC106402; AAI06403.1; -; mRNA.
DR EMBL; X62052; CAA43980.1; ALT_SEQ; mRNA.
DR PIR; A40357; A40357.
DR RefSeq; NP_001084035.1; NM_001090566.1.
DR RefSeq; XP_018092879.1; XM_018237390.1.
DR AlphaFoldDB; Q08820; -.
DR SMR; Q08820; -.
DR DNASU; 399267; -.
DR GeneID; 399267; -.
DR KEGG; xla:399267; -.
DR CTD; 399267; -.
DR Xenbase; XB-GENE-482735; hoxd1.S.
DR OMA; TERQHEY; -.
DR OrthoDB; 1216870at2759; -.
DR Proteomes; UP000186698; Chromosome 9_10S.
DR Bgee; 399267; Expressed in gastrula and 2 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0030902; P:hindbrain development; IMP:UniProtKB.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR046327; HXA1/B1/D1.
DR PANTHER; PTHR45946; PTHR45946; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..300
FT /note="Homeobox protein Hox-D1"
FT /id="PRO_0000200203"
FT DNA_BIND 200..259
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 148..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 251..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 175..180
FT /note="Antp-type hexapeptide"
FT COMPBIAS 286..300
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 41
FT /note="S -> P (in Ref. 2; AAA03480)"
FT /evidence="ECO:0000305"
FT CONFLICT 75
FT /note="P -> A (in Ref. 4; CAA43980)"
FT /evidence="ECO:0000305"
FT CONFLICT 128..129
FT /note="RT -> SP (in Ref. 1; AAA49745)"
FT /evidence="ECO:0000305"
FT CONFLICT 157
FT /note="S -> L (in Ref. 1; AAA49745)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 300 AA; 33333 MW; B3C65BCBE83F1811 CRC64;
MNSYLEYTSC GDVLAFSPKF CRSDHRNMNL QPYPRSGADH SFMPVGGVPG SVAHQAPHQS
PALYAPCSLD VAYEPTPPSD YSFLHSSPDY DYYGSNHQIE ETGGHIPYGS SLFPGNGSYI
LNGQLSYRTL GEETQMAQCK EPLEVYPGGN LQSISPSPGT YPKPASPASD SYVSTFDWMK
VKRNPPKKSI PSEYGVTSPP CNVRTNFTTK QLTELEKEFH FNKYLTRARR IEIANSLQLN
DTQVKIWFQN RRMKQKKRER EGTLPNSPPS GPASNFCVKP PHLKSVNETA TLSPSKDASP
