HXD1_XENTR
ID HXD1_XENTR Reviewed; 301 AA.
AC Q28IU6;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Homeobox protein Hox-D1 {ECO:0000250|UniProtKB:Q08820};
GN Name=hoxd1 {ECO:0000312|EMBL:CAJ83247.1}; ORFNames=TNeu039b14.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1] {ECO:0000312|EMBL:CAJ83247.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Neurula {ECO:0000312|EMBL:CAJ83247.1};
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000312|EMBL:CAJ83247.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Gastrula {ECO:0000312|EMBL:AAI60395.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis. Acts on the
CC anterior body structures. Acts downstream of meis3 to pattern the
CC hindbrain (By similarity). {ECO:0000250|UniProtKB:Q08820}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q08820,
CC ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. Labial subfamily.
CC {ECO:0000255}.
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DR EMBL; CR760220; CAJ83247.1; -; mRNA.
DR EMBL; BC160395; AAI60395.1; -; mRNA.
DR EMBL; BC170961; AAI70961.1; -; mRNA.
DR EMBL; BC170965; AAI70965.1; -; mRNA.
DR RefSeq; NP_001016678.1; NM_001016678.2.
DR AlphaFoldDB; Q28IU6; -.
DR SMR; Q28IU6; -.
DR STRING; 8364.ENSXETP00000051086; -.
DR PaxDb; Q28IU6; -.
DR Ensembl; ENSXETT00000003767; ENSXETP00000003767; ENSXETG00000001801.
DR GeneID; 549432; -.
DR KEGG; xtr:549432; -.
DR CTD; 3231; -.
DR Xenbase; XB-GENE-482731; hoxd1.
DR eggNOG; KOG0489; Eukaryota.
DR HOGENOM; CLU_058839_0_0_1; -.
DR InParanoid; Q28IU6; -.
DR OMA; MSSYLEY; -.
DR OrthoDB; 1216870at2759; -.
DR PhylomeDB; Q28IU6; -.
DR TreeFam; TF317730; -.
DR Proteomes; UP000008143; Chromosome 9.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000001801; Expressed in gastrula and 28 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR046327; HXA1/B1/D1.
DR PANTHER; PTHR45946; PTHR45946; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..301
FT /note="Homeobox protein Hox-D1"
FT /id="PRO_0000373063"
FT DNA_BIND 200..259
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 255..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 178..183
FT /note="Antp-type hexapeptide"
FT /evidence="ECO:0000255"
FT COMPBIAS 270..301
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 301 AA; 33189 MW; C7E2A4AB2AE27A63 CRC64;
MNSYLEYTSC GDVVAFSPKF CRSDQRNMTL QPYPGSGADH PFMPVGGVPG SVAHQASHQS
PALYAPCSLD VAYEPPPPSD YSFLHSSTDY DYYGSNHLVE ETGGHIPYGS SVFPGNGSYI
LNGQLSYRTL GEETQMAQIA QCKEPLEVYP GGNLQSISPS PGTYPKPASP ASDTHVSTFD
WMKVKRNPPK KSLQSEYGVA SPPCTVRTNF TTKQLTELEK EFHFNKYLTR ARRIEIANSL
QLNDTQVKIW FQNRRMKQKK REREGSLPNS PPSGPASSIC VKTPLSKSVH ETATLSPSKD
V