ID   HXD3_HAPBU              Reviewed;         404 AA.
AC   A8DT10;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Homeobox protein Hox-D3;
GN   Name=hoxd3a;
OS   Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX   NCBI_TaxID=8153;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=17845724; DOI=10.1186/1471-2164-8-317;
RA   Hoegg S., Boore J.L., Kuehl J.V., Meyer A.;
RT   "Comparative phylogenomic analyses of teleost fish Hox gene clusters:
RT   lessons from the cichlid fish Astatotilapia burtoni.";
RL   BMC Genomics 8:317-317(2007).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; EF594315; ABS70796.1; -; Genomic_DNA.
DR   AlphaFoldDB; A8DT10; -.
DR   SMR; A8DT10; -.
DR   STRING; 8153.XP_005921524.1; -.
DR   Proteomes; UP000264840; Whole Genome Shotgun Assembly.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR025281; DUF4074.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF13293; DUF4074; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..404
FT                   /note="Homeobox protein Hox-D3"
FT                   /id="PRO_0000363946"
FT   DNA_BIND        169..228
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..122
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          134..173
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          227..256
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          372..404
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           127..132
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        28..47
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        66..122
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        134..150
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        382..396
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   404 AA;  43936 MW;  3338874982D17004 CRC64;
     MQKATYYDNS GLFGGYTYPK PDSYNYGPAH QSYPTSNIDS DYQGSVCPIQ TAAVRPPALK
     DSDLNGDCMR QSSSQNNNNN QATSISEQQA PPLSASSPSS NSSASQKKKS PSSSASSSAT
     PALTKQIFPW MKETRQNSKQ KNSNNCATAG SDHDGGEVSD EKSPPGPASK RVKTAYTSAQ
     LVELEKEFHF NRYLCRPRRV EMANLLNLTE RQIKIWFQNR RMKYKKDQKS KGLAHSPLGH
     SPDRSPPLSG PNHIGYSGQL QNVNSLSYDA PSPPSFAKPQ QNMYGLAAYT APLGGCIPQQ
     KRYPGSEYEH HGMQSNGSFA NANLQSSPVY VGGNFVDSMP ASGPMFNLGH LPHPSSTSVD
     YSCAAQIPGN HHHGPCDPHP TYTDLTSHQA SQGRIQEAPK LTHL