ID   HXD3_RAT                Reviewed;         114 AA.
AC   P18867;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   25-MAY-2022, entry version 122.
DE   RecName: Full=Homeobox protein Hox-D3;
DE   AltName: Full=Homeobox protein R6;
DE   Flags: Fragment;
GN   Name=Hoxd3; Synonyms=Hoxd-3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley;
RX   PubMed=2907739; DOI=10.1242/dev.103.3.601;
RA   Falzon M., Chung S.Y.;
RT   "The expression of rat homeobox-containing genes is developmentally
RT   regulated and tissue specific.";
RL   Development 103:601-610(1988).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Predominantly spinal cord and kidney.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; M37569; AAA41345.1; -; mRNA.
DR   PIR; E43559; E43559.
DR   AlphaFoldDB; P18867; -.
DR   SMR; P18867; -.
DR   STRING; 10116.ENSRNOP00000034938; -.
DR   PaxDb; P18867; -.
DR   PRIDE; P18867; -.
DR   UCSC; RGD:1588601; rat.
DR   RGD; 1588601; Hoxd3.
DR   eggNOG; KOG0489; Eukaryota.
DR   InParanoid; P18867; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:RGD.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; ISO:RGD.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; ISO:RGD.
DR   GO; GO:0051216; P:cartilage development; ISO:RGD.
DR   GO; GO:0007160; P:cell-matrix adhesion; ISO:RGD.
DR   GO; GO:0048704; P:embryonic skeletal system morphogenesis; ISO:RGD.
DR   GO; GO:0021615; P:glossopharyngeal nerve morphogenesis; ISO:RGD.
DR   GO; GO:0007219; P:Notch signaling pathway; ISO:RGD.
DR   GO; GO:0010628; P:positive regulation of gene expression; ISO:RGD.
DR   GO; GO:0045666; P:positive regulation of neuron differentiation; ISO:RGD.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0030878; P:thyroid gland development; ISO:RGD.
DR   GO; GO:0006351; P:transcription, DNA-templated; ISO:RGD.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           <1..>114
FT                   /note="Homeobox protein Hox-D3"
FT                   /id="PRO_0000200206"
FT   DNA_BIND        11..70
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          70..93
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT   NON_TER         114
SQ   SEQUENCE   114 AA;  13044 MW;  C4192BE1F2C7F591 CRC64;
     TGRTRAHRAR HPRGCTAYTS AQLVELEKEF HFNRYLCRRR RVEMANLLNL TERQIKIWFQ
     NRRMKYKKDQ KAKGILHSPA GQSPERTPPL GGAAATCLLR PAAAVPAWPT THPS