ID   HXD3_XENLA              Reviewed;         413 AA.
AC   A1L2P5;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Homeobox protein Hox-D3;
GN   Name=hoxd3;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Forelimb, and Hind limb;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-17 is the initiator.
CC       {ECO:0000305}.
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DR   EMBL; BC129640; AAI29641.1; -; mRNA.
DR   RefSeq; NP_001091156.1; NM_001097687.1.
DR   RefSeq; XP_018089363.1; XM_018233874.1.
DR   RefSeq; XP_018089364.1; XM_018233875.1.
DR   AlphaFoldDB; A1L2P5; -.
DR   SMR; A1L2P5; -.
DR   GeneID; 100036911; -.
DR   KEGG; xla:100036911; -.
DR   CTD; 100036911; -.
DR   Xenbase; XB-GENE-865180; hoxd3.L.
DR   OrthoDB; 934469at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 100036911; Expressed in neurula embryo and 4 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR025281; DUF4074.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF13293; DUF4074; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..413
FT                   /note="Homeobox protein Hox-D3"
FT                   /id="PRO_0000363948"
FT   DNA_BIND        178..237
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          36..181
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          236..265
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          381..413
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           142..147
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        39..63
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        75..181
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        243..265
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        392..406
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   413 AA;  45375 MW;  D17893B1155687D5 CRC64;
     MFIDKGASPL PIREAKMQKT AYYENSGLFG GYTYAKPESY SYGPSQQQYP QSSLDNDYPS
     TACSVQPAAI RAPNHKTNDI SNSCMRTTSS QNSNQTPSIS NQQHQAPSLP PSSPSHSNTS
     AQKKSKSSNS SGSSQSTMNK QIFPWMKESR QNSKQKNSSS TPPAGENCEE KSPTGPSSKR
     VRTAYTSAQL VELEKEFHFN RYLCRPRRVE MANLLNLTER QIKIWFQNRR MKYKKDQKAK
     GIMHSPTGQS PDRSPPLSGP NLVGYSSQLP TVNSLSYDAP SPTSFAKSQQ NMYGLAAYTA
     PLSSCLPQQK RYPGAEYEHH TMQGNSGFAN PNLQGSPVYV GGNFVDSMPA SGPMFNVGHL
     SHPSSASVDY SCAAQIPGNH HHGPCDPHPT YTDLSSHHTT QGRMQEAPKL THL