ID   HXD4B_TAKRU             Reviewed;         249 AA.
AC   Q1KKR6;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Homeobox protein Hox-D4b;
GN   Name=hoxd4b;
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16636282; DOI=10.1073/pnas.0601492103;
RA   Lee A.P., Koh E.G.L., Tay A., Brenner S., Venkatesh B.;
RT   "Highly conserved syntenic blocks at the vertebrate Hox loci and conserved
RT   regulatory elements within and outside Hox gene clusters.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:6994-6999(2006).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. Deformed subfamily.
CC       {ECO:0000305}.
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DR   EMBL; DQ481669; ABF22478.1; -; Genomic_DNA.
DR   RefSeq; XP_003963897.1; XM_003963848.2.
DR   AlphaFoldDB; Q1KKR6; -.
DR   SMR; Q1KKR6; -.
DR   Ensembl; ENSTRUT00000068559; ENSTRUP00000081559; ENSTRUG00000028105.
DR   GeneID; 101070735; -.
DR   KEGG; tru:101070735; -.
DR   GeneTree; ENSGT00940000158988; -.
DR   InParanoid; Q1KKR6; -.
DR   OMA; GGGYQPM; -.
DR   OrthoDB; 1154159at2759; -.
DR   Proteomes; UP000005226; Chromosome 4.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017995; Homeobox_antennapedia.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00025; ANTENNAPEDIA.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..249
FT                   /note="Homeobox protein Hox-D4b"
FT                   /id="PRO_0000265996"
FT   DNA_BIND        156..215
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          13..92
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          213..249
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           135..140
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        26..45
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        66..80
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        229..249
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   249 AA;  28478 MW;  5FA9F9958FCF3A15 CRC64;
     MESYVMSCKY AEPQFPPCEE DYSNFSDQGG YYNNPQDSGS YGGGYQSVQP PPPPYAPQQS
     SYHPRSVQEQ HREDAEERAQ HPAASFPGYR EVDASGKQGY SAGDLQCQAW MTCAKSPQVQ
     RKVVCHGKDK SPIVVYPWMK KVHVAQVNPN HPGPEPKRLR TAYTRQQVLE LEKEFHFSRY
     LTRRRRVEVA HTLCLSERQV KVWFQNRRMR WKKDHKLPNT KGRSKNKKTT DSNNNNSGGA
     TSVKAAITV