HXD4_CHICK
ID HXD4_CHICK Reviewed; 235 AA.
AC P17278;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1990, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Homeobox protein Hox-D4;
DE AltName: Full=Homeobox protein Hox-A;
DE Short=Chox-A;
GN Name=HOXD4; Synonyms=CHOX-A, HOXD-4;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX PubMed=1970866; DOI=10.1093/nar/18.7.1739;
RA Sasaki H., Yokoyama E., Kuroiwa A.;
RT "Specific DNA binding of the two chicken Deformed family homeodomain
RT proteins, Chox-1.4 and Chox-a.";
RL Nucleic Acids Res. 18:1739-1747(1990).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis. Binds to sites in
CC the 5'-flanking sequence of its coding region with various affinities.
CC The consensus sequences of the high and low affinity binding sites are
CC 5'-TAATGA[CG]-3' and 5'-CTAATTTT-3'.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. Deformed subfamily.
CC {ECO:0000305}.
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DR EMBL; X52671; CAA36897.1; -; Genomic_DNA.
DR EMBL; X52672; CAA36898.1; -; mRNA.
DR PIR; S09256; S09256.
DR AlphaFoldDB; P17278; -.
DR SMR; P17278; -.
DR STRING; 9031.ENSGALP00000037899; -.
DR PaxDb; P17278; -.
DR VEuPathDB; HostDB:geneid_424139; -.
DR eggNOG; KOG0489; Eukaryota.
DR InParanoid; P17278; -.
DR PhylomeDB; P17278; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017995; Homeobox_antennapedia.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00025; ANTENNAPEDIA.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..235
FT /note="Homeobox protein Hox-D4"
FT /id="PRO_0000200213"
FT DNA_BIND 144..203
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 66..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 202..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 123..128
FT /note="Antp-type hexapeptide"
FT COMPBIAS 209..235
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 235 AA; 26662 MW; B7115D434033E4B5 CRC64;
MAMSSYMVNS YVDPKFPPCE EYLQSSYLGE QGAEYYGASQ GSDFQHQGLY PRSNYSEQPF
WLAGAQGSAV QPRGHGQEQS APPSHFPGQA EHCPPPPCPI PSCGQQPALK APHGSAVKQP
AVVYPWMKKV HVNSVNPNYS GGEPKRSRTA YTRQQVLELE KEFHFNRYLT RRRRIEIAHT
LCLSERQIKI WFQNRRMKWK KDHKLPNTKG RSSSSASNPH LQTVPKDHQT DLTTL