ID   HXD4_SHEEP              Reviewed;          46 AA.
AC   P14159;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Homeobox protein Hox-D4;
DE   AltName: Full=Homeobox protein Hox-8.1;
DE            Short=OHox-8.1;
DE   Flags: Fragment;
GN   Name=HOXD4; Synonyms=HOX-8.1;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2898416; DOI=10.1016/0378-1119(88)90524-0;
RA   Choi C.-L., Hudson P., Stauder A., Pietersz G., Brandon M.;
RT   "Molecular cloning and characterization of ovine homeo-box-containing
RT   genes.";
RL   Gene 63:187-197(1988).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. {ECO:0000250}.
CC   -!- SUBUNIT: Forms a DNA-binding heterodimer with transcription factor
CC       PBX1. {ECO:0000250|UniProtKB:P09016}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. Deformed subfamily.
CC       {ECO:0000305}.
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DR   EMBL; M29539; AAA31539.1; -; Genomic_DNA.
DR   PIR; B30474; B30474.
DR   AlphaFoldDB; P14159; -.
DR   SMR; P14159; -.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           <1..>46
FT                   /note="Homeobox protein Hox-D4"
FT                   /id="PRO_0000200212"
FT   DNA_BIND        <1..>46
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   NON_TER         1
FT   NON_TER         46
SQ   SEQUENCE   46 AA;  5628 MW;  36AE4C871B9F6A54 CRC64;
     VNSNYTGGEP KRSRTAYTRQ QVLELEKEFL FNRYLTRRRR IQHTLT