HXD8_CHICK
ID HXD8_CHICK Reviewed; 188 AA.
AC P23459;
DT 01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1991, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Homeobox protein Hox-D8;
DE AltName: Full=Homeobox protein Hox-M;
DE Short=Chox-M;
GN Name=HOXD8; Synonyms=CHOX-M;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1674560;
RA Crompton M.R., McGregor A.D., Goodwin G.H.;
RT "cDNA cloning of a homeobox-containing gene expressed in avian myeloblastic
RT virus-transformed chicken monoblastic leukaemia cells.";
RL Leukemia 5:357-360(1991).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR EMBL; X57158; CAA40445.1; -; mRNA.
DR PIR; I50145; I50145.
DR RefSeq; NP_997060.1; NM_207177.1.
DR AlphaFoldDB; P23459; -.
DR SMR; P23459; -.
DR STRING; 9031.ENSGALP00000037897; -.
DR Ensembl; ENSGALT00000064752; ENSGALP00000052191; ENSGALG00000037272.
DR GeneID; 396301; -.
DR KEGG; gga:396301; -.
DR CTD; 3234; -.
DR VEuPathDB; HostDB:geneid_396301; -.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000161653; -.
DR HOGENOM; CLU_061398_1_0_1; -.
DR InParanoid; P23459; -.
DR OrthoDB; 976319at2759; -.
DR PhylomeDB; P23459; -.
DR PRO; PR:P23459; -.
DR Proteomes; UP000000539; Chromosome 7.
DR Bgee; ENSGALG00000037272; Expressed in kidney and 4 other tissues.
DR ExpressionAtlas; P23459; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR000047; HTH_motif.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..188
FT /note="Homeobox protein Hox-D8"
FT /id="PRO_0000200218"
FT DNA_BIND 95..154
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 152..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 83..88
FT /note="Antp-type hexapeptide"
SQ SEQUENCE 188 AA; 21729 MW; D4560E8807FE29FE CRC64;
MSSYFVNPLY SKYKAAAAAA AAVAAGEPLP APYYDCHFAP ERQQIFTTQQ EAELVQYPDC
KSSSANIGEE PDHLNQSSSP AQMFPWMRPQ AAPGRRRGRQ TYSRFQTLEL EKEFLFNPYL
TRKRRIEVSH ALGLTERQVK IWFQNRRMKW KKENNKDKFP ASKQEGKEGE AKKETHDLED
DRAESHTN
