ID   HXD8_HETFR              Reviewed;         240 AA.
AC   Q9IA12;
DT   11-JUL-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Homeobox protein Hox-D8;
GN   Name=HOXD8;
OS   Heterodontus francisci (Horn shark) (Cestracion francisci).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Elasmobranchii; Galeomorphii; Heterodontoidea; Heterodontiformes;
OC   Heterodontidae; Heterodontus.
OX   NCBI_TaxID=7792;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10677514; DOI=10.1073/pnas.030539697;
RA   Kim C.B., Amemiya C., Bailey W., Kawasaki K., Mezey J., Miller W.,
RA   Minoshima S., Shimizu N., Wagner G., Ruddle F.;
RT   "Hox cluster genomics in the horn shark, Heterodontus francisci.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:1655-1660(2000).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; AF224263; AAF44632.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9IA12; -.
DR   SMR; Q9IA12; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..240
FT                   /note="Homeobox protein Hox-D8"
FT                   /id="PRO_0000200219"
FT   DNA_BIND        147..206
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          112..136
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          204..240
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           135..140
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        204..221
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   240 AA;  28127 MW;  4B9CC0022CE58105 CRC64;
     MSSYFVNPFY SKYKPGEALS PTYYDCRFPQ DVTSRHAVVY GPSSGASFQH PAQVQDFYHH
     GTSALPNTGF QQNPCGITCH GDPSKFYGYD NLQRQQIFTT QQEADLVQYP DCKSSSSNIG
     EEPEHLNQNS SPTQMFPWMR PQAAPGRRRG RQTYSRFQTL ELEKEFLFNP YLTRKRRIEV
     SHALGLTERQ VKIWFQNRRM KWKKENNKDK FPTSRNDDED EEVKKEQEEP EQETTEKETK