HXD8_MOUSE
ID HXD8_MOUSE Reviewed; 289 AA.
AC P23463; A2ASN2;
DT 01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 4.
DT 03-AUG-2022, entry version 169.
DE RecName: Full=Homeobox protein Hox-D8;
DE AltName: Full=Homeobox protein Hox-4.3;
DE AltName: Full=Homeobox protein Hox-5.4;
GN Name=Hoxd8; Synonyms=Hox-4.3, Hoxd-8;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1982431;
RA Izpisua-Belmonte J.-C., Dolle P., Renucci A., Zappavigna V.,
RA Falkenstein H., Duboule D.;
RT "Primary structure and embryonic expression pattern of the mouse Hox-4.3
RT homeobox gene.";
RL Development 110:733-745(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 191-289.
RX PubMed=1675873; DOI=10.1016/0167-4781(91)90020-m;
RA Sadoul R., Featherstone M.;
RT "Sequence analysis of the homeobox-containing exon of the murine Hox-4.3
RT homeogene.";
RL Biochim. Biophys. Acta 1089:259-261(1991).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 195-254.
RX PubMed=1683707; DOI=10.1073/pnas.88.23.10706;
RA Singh G., Kaur S., Stock J.L., Jenkins N.A., Gilbert D.J., Copeland N.G.,
RA Potter S.S.;
RT "Identification of 10 murine homeobox genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 88:10706-10710(1991).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 192-260.
RX PubMed=1348361; DOI=10.1073/pnas.89.7.2883;
RA Nazarali A., Kim Y., Nirenberg M.;
RT "Hox-1.11 and Hox-4.9 homeobox genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 89:2883-2887(1992).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR EMBL; X56561; CAA39911.1; -; Genomic_DNA.
DR EMBL; AL928644; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; M87803; AAA37852.1; -; Genomic_DNA.
DR CCDS; CCDS16143.1; -.
DR PIR; A43562; A43562.
DR PIR; S16177; A41605.
DR RefSeq; NP_032302.2; NM_008276.3.
DR AlphaFoldDB; P23463; -.
DR SMR; P23463; -.
DR STRING; 10090.ENSMUSP00000019749; -.
DR PhosphoSitePlus; P23463; -.
DR PaxDb; P23463; -.
DR PRIDE; P23463; -.
DR ProteomicsDB; 266936; -.
DR Antibodypedia; 33911; 294 antibodies from 30 providers.
DR DNASU; 15437; -.
DR Ensembl; ENSMUST00000019749; ENSMUSP00000019749; ENSMUSG00000027102.
DR GeneID; 15437; -.
DR KEGG; mmu:15437; -.
DR UCSC; uc008kea.2; mouse.
DR CTD; 3234; -.
DR MGI; MGI:96209; Hoxd8.
DR VEuPathDB; HostDB:ENSMUSG00000027102; -.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000161653; -.
DR HOGENOM; CLU_061398_1_0_1; -.
DR InParanoid; P23463; -.
DR OMA; CHREPAK; -.
DR OrthoDB; 976319at2759; -.
DR PhylomeDB; P23463; -.
DR TreeFam; TF316310; -.
DR BioGRID-ORCS; 15437; 3 hits in 73 CRISPR screens.
DR ChiTaRS; Hoxd8; mouse.
DR PRO; PR:P23463; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; P23463; protein.
DR Bgee; ENSMUSG00000027102; Expressed in embryonic post-anal tail and 165 other tissues.
DR ExpressionAtlas; P23463; baseline and differential.
DR Genevisible; P23463; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; ISO:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IMP:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IGI:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0048705; P:skeletal system morphogenesis; IMP:MGI.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..289
FT /note="Homeobox protein Hox-D8"
FT /id="PRO_0000200217"
FT DNA_BIND 195..254
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 62..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 162..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 252..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 183..188
FT /note="Antp-type hexapeptide"
FT COMPBIAS 67..83
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..125
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 252..280
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 289 AA; 31363 MW; E9996BB134A3A22E CRC64;
MSSYFVNPLY SKYKAAAAAA AAAAAAAAGE AINPTYYDCH FAPEVSGRHA AALQLYGNSA
AGFPHAHPHP HPHPSPPPGC GGGGGPGPGQ DYFHAGAGSP TAAYQAAPPP PHPPPPPPPP
PCGGIACHGE PAKFYGYDNL QRQPIFTTQQ EAELVQYPDC KSSSGNIGED PDHLNQSSSP
SQMFPWMRPQ AAPGRRRGRQ TYSRFQTLEL EKEFLFNPYL TRKRRIEVSH TLALTERQVK
IWFQNRRMKW KKENNKDKFP ASRPEAKDGD PKKEVSGLEE DGAEGCPTN
