HXD9_MOUSE
ID HXD9_MOUSE Reviewed; 339 AA.
AC P28357; A2ASM9; Q3UMQ3; Q3UYS2;
DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-1992, sequence version 1.
DT 03-AUG-2022, entry version 174.
DE RecName: Full=Homeobox protein Hox-D9;
DE AltName: Full=Homeobox protein Hox-4.4;
DE AltName: Full=Homeobox protein Hox-5.2;
GN Name=Hoxd9; Synonyms=Hox-4.4, Hoxd-9;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1348690; DOI=10.1002/j.1460-2075.1992.tb05190.x;
RA Renucci A.G.P., Zappavigna V., Zakany J., Izpisua-Belmonte J.-C.,
RA Buerki K., Douboule D.;
RT "Comparison of mouse and human HOX-4 complexes defines conserved sequences
RT involved in the regulation of Hox-4.4.";
RL EMBO J. 11:1459-1468(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Lung, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE OF 272-331.
RX PubMed=2569970; DOI=10.1002/j.1460-2075.1989.tb03535.x;
RA Dolle P., Duboule D.;
RT "Two gene members of the murine HOX-5 complex show regional and cell-type
RT specific expression in developing limbs and gonads.";
RL EMBO J. 8:1507-1515(1989).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 272-331, AND DEVELOPMENTAL STAGE.
RX PubMed=2569969; DOI=10.1002/j.1460-2075.1989.tb03534.x;
RA Duboule D., Dolle P.;
RT "The structural and functional organization of the murine HOX gene family
RT resembles that of Drosophila homeotic genes.";
RL EMBO J. 8:1497-1505(1989).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- DEVELOPMENTAL STAGE: Expressed in the developing limb buds. Expressed
CC in the posterior-most regions of the fetus. Strongly expressed in 12.5
CC day old fetuses in both spinal cord and pre-vertebral column with an
CC anterior boundary of expression lying at the level of the first lumbar
CC pre-vertebrae. {ECO:0000269|PubMed:2569969}.
CC -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
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DR EMBL; X62669; CAA44542.1; -; Genomic_DNA.
DR EMBL; AK134427; BAE22140.1; -; mRNA.
DR EMBL; AK144746; BAE26045.1; -; mRNA.
DR EMBL; AL928644; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC019150; AAH19150.1; -; mRNA.
DR EMBL; X14714; CAB57813.1; -; Genomic_DNA.
DR CCDS; CCDS16142.1; -.
DR PIR; S20880; S20880.
DR RefSeq; NP_038583.1; NM_013555.4.
DR AlphaFoldDB; P28357; -.
DR BMRB; P28357; -.
DR SMR; P28357; -.
DR BioGRID; 200399; 3.
DR IntAct; P28357; 3.
DR STRING; 10090.ENSMUSP00000058490; -.
DR PhosphoSitePlus; P28357; -.
DR MaxQB; P28357; -.
DR PaxDb; P28357; -.
DR PRIDE; P28357; -.
DR ProteomicsDB; 273288; -.
DR Antibodypedia; 33907; 207 antibodies from 28 providers.
DR DNASU; 15438; -.
DR Ensembl; ENSMUST00000059272; ENSMUSP00000058490; ENSMUSG00000043342.
DR GeneID; 15438; -.
DR KEGG; mmu:15438; -.
DR UCSC; uc008kdz.1; mouse.
DR CTD; 3235; -.
DR MGI; MGI:96210; Hoxd9.
DR VEuPathDB; HostDB:ENSMUSG00000043342; -.
DR eggNOG; KOG0487; Eukaryota.
DR GeneTree; ENSGT00940000161503; -.
DR HOGENOM; CLU_071854_0_0_1; -.
DR InParanoid; P28357; -.
DR OMA; MRSWMEP; -.
DR OrthoDB; 976319at2759; -.
DR PhylomeDB; P28357; -.
DR TreeFam; TF317819; -.
DR BioGRID-ORCS; 15438; 0 hits in 74 CRISPR screens.
DR ChiTaRS; Hoxd9; mouse.
DR PRO; PR:P28357; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; P28357; protein.
DR Bgee; ENSMUSG00000043342; Expressed in gonadal ridge and 148 other tissues.
DR Genevisible; P28357; MM.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0003677; F:DNA binding; IDA:MGI.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:MGI.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; ISO:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0008344; P:adult locomotory behavior; IGI:MGI.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IMP:MGI.
DR GO; GO:0035115; P:embryonic forelimb morphogenesis; IMP:MGI.
DR GO; GO:0048706; P:embryonic skeletal system development; IMP:MGI.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; IGI:MGI.
DR GO; GO:0035136; P:forelimb morphogenesis; IGI:MGI.
DR GO; GO:0035137; P:hindlimb morphogenesis; IGI:MGI.
DR GO; GO:0030879; P:mammary gland development; IGI:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0048935; P:peripheral nervous system neuron development; IGI:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:0009954; P:proximal/distal pattern formation; IMP:MGI.
DR GO; GO:0010468; P:regulation of gene expression; IGI:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007338; P:single fertilization; IGI:MGI.
DR GO; GO:0007519; P:skeletal muscle tissue development; IGI:MGI.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR006711; Hox9_activation_N.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF04617; Hox9_act; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..339
FT /note="Homeobox protein Hox-D9"
FT /id="PRO_0000200221"
FT DNA_BIND 272..331
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 114..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 211..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..186
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 339 AA; 34992 MW; 370DC47C6929F7E1 CRC64;
MSSSGTLSNY YVDSLIGHEG DEVFAARFGP PGPGTQGRPA GVADGPAAAT AEFASCSFAP
KSSVFSASWS AVAAQPPAAA TMSGLYHPYV SPPPLAAAEP GRYVRSWMEP LPGFPGGAGG
GGGSGGGGGG GPGPVPSPGG PANGRHYGIK PETGAAPAPA AASTSSSSST SSSSSSKRTE
CSAARESQGS GGPEFPCNSF LRDKAAAATG NGPGVGIGTG PGAVGSSEPS ACSDHPSPGC
SLKEEEKQPP QPPQQQLDPN NPAANWIHAR STRKKRCPYT KYQTLELEKE FLFNMYLTRD
RRYEVARILN LTERQVKIWF QNRRMKMKKM SKEKCPKGD
