ID   HXD9_RAT                Reviewed;         343 AA.
AC   B5DFK3;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Homeobox protein Hox-D9;
GN   Name=Hoxd9;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC169092; AAI69092.1; -; mRNA.
DR   RefSeq; NP_001166940.1; NM_001173469.1.
DR   AlphaFoldDB; B5DFK3; -.
DR   BMRB; B5DFK3; -.
DR   SMR; B5DFK3; -.
DR   STRING; 10116.ENSRNOP00000059218; -.
DR   PaxDb; B5DFK3; -.
DR   Ensembl; ENSRNOT00000065426; ENSRNOP00000059218; ENSRNOG00000001580.
DR   GeneID; 688999; -.
DR   KEGG; rno:688999; -.
DR   CTD; 3235; -.
DR   RGD; 1582908; Hoxd9.
DR   eggNOG; KOG0487; Eukaryota.
DR   InParanoid; B5DFK3; -.
DR   OrthoDB; 976319at2759; -.
DR   PhylomeDB; B5DFK3; -.
DR   PRO; PR:B5DFK3; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0003677; F:DNA binding; ISO:RGD.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISO:RGD.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; ISO:RGD.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; ISO:RGD.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR   GO; GO:0008344; P:adult locomotory behavior; ISO:RGD.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; ISO:RGD.
DR   GO; GO:0035115; P:embryonic forelimb morphogenesis; ISO:RGD.
DR   GO; GO:0048706; P:embryonic skeletal system development; ISO:RGD.
DR   GO; GO:0048704; P:embryonic skeletal system morphogenesis; ISO:RGD.
DR   GO; GO:0035136; P:forelimb morphogenesis; ISO:RGD.
DR   GO; GO:0035137; P:hindlimb morphogenesis; ISO:RGD.
DR   GO; GO:0030879; P:mammary gland development; ISO:RGD.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
DR   GO; GO:0048935; P:peripheral nervous system neuron development; ISO:RGD.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR   GO; GO:0009954; P:proximal/distal pattern formation; ISO:RGD.
DR   GO; GO:0010468; P:regulation of gene expression; ISO:RGD.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0007338; P:single fertilization; ISO:RGD.
DR   GO; GO:0007519; P:skeletal muscle tissue development; ISO:RGD.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR006711; Hox9_activation_N.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF04617; Hox9_act; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..343
FT                   /note="Homeobox protein Hox-D9"
FT                   /id="PRO_0000363862"
FT   DNA_BIND        276..335
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          113..196
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          220..267
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        160..186
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        247..261
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   343 AA;  35186 MW;  8D70DBB1459DC920 CRC64;
     MSSSGTLSNY YVDSLIGHEG DEVFAARFGP PGPGTQGRPA GVADGPAAAA EFASCSFAPK
     SSVFSASWSA VAAQPPAAAT MSGLYHPYVS PPPLAAAEPG RYVRSWMEPL PGFPGGAGGG
     GGSGGGGGGG SGGPGPVPSP GGPANGRHYG IKPETGAAPA PSAASTSSST SSSSSSKRTE
     CSAARESQGS GGPEFPCNSF LRDKAAAAAA AAAGNGPGVG IGTGPGTGGS SEPSACSDHP
     SPGCPLKEEE KQPPQPPQQQ LDPNNPAANW IHARSTRKKR CPYTKYQTLE LEKEFLFNMY
     LTRDRRYEVA RILNLTERQV KIWFQNRRMK MKKMSKEKCP KGD