HXDAA_DANRE
ID HXDAA_DANRE Reviewed; 332 AA.
AC Q90469; A8E5N6; O57371; P79730; P79731; Q6IQS5;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 4.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Homeobox protein Hox-D10a;
DE Short=Hox-D10;
DE AltName: Full=Homeobox protein Hox-C10;
GN Name=hoxd10a; Synonyms=hoxc10, hoxd10;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DEVELOPMENTAL STAGE.
RX PubMed=8808402; DOI=10.1016/0925-4773(95)00455-6;
RA van der Hoeven F., Sordino P., Fraudeau N., Izpisua-Belmonte J.-C.,
RA Duboule D.;
RT "Teleost HoxD and HoxA genes: comparison with tetrapods and functional
RT evolution of the HOXD complex.";
RL Mech. Dev. 54:9-21(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 9-233 AND 249-332.
RX PubMed=8917540; DOI=10.1073/pnas.93.23.13036;
RA Zardoya R., Abouheif E., Meyer A.;
RT "Evolutionary analyses of hedgehog and Hoxd-10 genes in fish species
RT closely related to the zebrafish.";
RL Proc. Natl. Acad. Sci. U.S.A. 93:13036-13041(1996).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 293-332.
RC TISSUE=Embryo;
RX PubMed=9425136; DOI=10.1242/dev.125.3.407;
RA Prince V.E., Joly L., Ekker M., Ho R.K.;
RT "Zebrafish hox genes: genomic organization and modified colinear expression
RT patterns in the trunk.";
RL Development 125:407-420(1998).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- DEVELOPMENTAL STAGE: First expressed at 11 hours post-fertilization
CC (hpf) in the dorsal presomitic mesoderm and neural keel at posterior
CC levels, extending into the ventral somitic mesoderm during budding. At
CC 22-26 hpf, expression decreases in the lateral and ventral mesoderm,
CC but is maintained in the neural rod. Expression decreases from
CC posterior to anterior with an anterior expression limit at somite 9. At
CC 24-26 hpf, posterior expression begins to weaken and is undetectable by
CC 40-56 hpf. {ECO:0000269|PubMed:8808402}.
CC -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
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DR EMBL; X87750; CAA61029.1; -; Genomic_DNA.
DR EMBL; BX322661; CAQ15519.1; -; Genomic_DNA.
DR EMBL; BC071329; AAH71329.1; -; mRNA.
DR EMBL; BC153658; AAI53659.1; -; mRNA.
DR EMBL; U51403; AAB38626.1; -; Genomic_DNA.
DR EMBL; U51421; AAB38643.1; -; Genomic_DNA.
DR EMBL; Y14542; CAA74877.1; -; mRNA.
DR RefSeq; NP_571241.2; NM_131166.2.
DR AlphaFoldDB; Q90469; -.
DR SMR; Q90469; -.
DR STRING; 7955.ENSDARP00000109229; -.
DR PaxDb; Q90469; -.
DR Ensembl; ENSDART00000080608; ENSDARP00000075055; ENSDARG00000057859.
DR GeneID; 30404; -.
DR KEGG; dre:30404; -.
DR CTD; 30404; -.
DR ZFIN; ZDB-GENE-990415-116; hoxd10a.
DR eggNOG; KOG0487; Eukaryota.
DR GeneTree; ENSGT00940000158266; -.
DR HOGENOM; CLU_057871_0_0_1; -.
DR InParanoid; Q90469; -.
DR OMA; SYGMQTC; -.
DR OrthoDB; 976319at2759; -.
DR PhylomeDB; Q90469; -.
DR TreeFam; TF317819; -.
DR PRO; PR:Q90469; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 9.
DR Bgee; ENSDARG00000057859; Expressed in tail bud paraxial mesoderm and 15 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR046333; HXA10/ABDB-like.
DR PANTHER; PTHR45874; PTHR45874; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..332
FT /note="Homeobox protein Hox-D10a"
FT /id="PRO_0000200229"
FT DNA_BIND 258..317
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 194..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 17
FT /note="Missing (in Ref. 1; CAA61029)"
FT /evidence="ECO:0000305"
FT CONFLICT 198..200
FT /note="AHD -> RTI (in Ref. 1; CAA61029)"
FT /evidence="ECO:0000305"
FT CONFLICT 215
FT /note="K -> Q (in Ref. 4; AAB38626)"
FT /evidence="ECO:0000305"
FT CONFLICT 241
FT /note="K -> KA (in Ref. 1; CAA61029)"
FT /evidence="ECO:0000305"
FT CONFLICT 292
FT /note="S -> T (in Ref. 4; AAB38643)"
FT /evidence="ECO:0000305"
FT CONFLICT 296
FT /note="N -> S (in Ref. 1; CAA61029)"
FT /evidence="ECO:0000305"
FT CONFLICT 301
FT /note="Q -> R (in Ref. 5; CAA74877)"
FT /evidence="ECO:0000305"
FT CONFLICT 330
FT /note="T -> N (in Ref. 1; CAA61029 and 5; CAA74877)"
FT /evidence="ECO:0000305"
FT CONFLICT 332
FT /note="S -> FVSTQNKCKSKT (in Ref. 1; CAA61029 and 5;
FT CAA74877)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 332 AA; 37592 MW; 7ABE463B49EB273B CRC64;
MSFPNSSPAA NTFLVDSLIG ACRTDFYSSS NMYMPAATAE MGTYGMQTCG LLPALGKRGE
VNHQNMDMTV HSYIPQTDTW ADPSRSCRLE QPLNQMSTCT FSQSIKEETN CCMYSDKRAK
VSSSEIPAYS SLIPESCSVD SPEIPVPGYF RLSQTYATAK NPDYDNETMS PNTTLMQLNR
ATPKAQSTPF VEVEKKLAHD RDTRSSSPAQ SPEPKVSTLE EKNCSTEASV SSPELPHREG
KESKNDTPTS NWLTAKSGRK KRCPYTKHQT LELEKEFLFN MYLTRERRLE ISKSVNLTDR
QVKIWFQNRR MKLKKMSREN RIRELTSNLT FS
