ID   HXDAA_TAKRU             Reviewed;         336 AA.
AC   Q1KKT0;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Homeobox protein Hox-D10a;
GN   Name=hoxd10a;
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16636282; DOI=10.1073/pnas.0601492103;
RA   Lee A.P., Koh E.G.L., Tay A., Brenner S., Venkatesh B.;
RT   "Highly conserved syntenic blocks at the vertebrate Hox loci and conserved
RT   regulatory elements within and outside Hox gene clusters.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:6994-6999(2006).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
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DR   EMBL; DQ481668; ABF22464.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q1KKT0; -.
DR   SMR; Q1KKT0; -.
DR   STRING; 31033.ENSTRUP00000044927; -.
DR   eggNOG; KOG0487; Eukaryota.
DR   InParanoid; Q1KKT0; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR046333; HXA10/ABDB-like.
DR   PANTHER; PTHR45874; PTHR45874; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..336
FT                   /note="Homeobox protein Hox-D10a"
FT                   /id="PRO_0000265999"
FT   DNA_BIND        262..321
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          161..256
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   336 AA;  37706 MW;  4F666D31642C94FF CRC64;
     MSFPSSSPAA NTFLVDSLIS ACRTDSFYTG SSMYMPPGSE MGTYGMQTCG LLPAFSKRGE
     VNHQNVGMNV HSYIPQIDNW TDPSRPCRIE SSNQDVQTTH SHQNIKEESN CCMYSDKRVP
     KVSSSEVPVY SNVAPESCPV DGPEIPVPGY FRLSQTYATG KHQEPYCHDP PDQSPTLIQL
     TPKPQPAPAS ATFADGESEK NKVPPEPATS RTPIQVESPK SATVEKICSP EASASSPELL
     QKEGKDSKSD QPANNWLTAK SGRKKRCPYT KHQTLELEKE FLFNMYLTRE RRLEISRSVN
     LTDRQVKIWF QNRRMKLKKM SRENRIRELT SNLTFS