HXDBA_DANRE
ID HXDBA_DANRE Reviewed; 276 AA.
AC Q90470; O57372; Q29RC6; Q4JMC9;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Homeobox protein Hox-D11a;
DE Short=Hox-D11;
DE AltName: Full=Homeobox protein Hox-C11;
GN Name=hoxd11a; Synonyms=hoxc11, hoxd11;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 14-276, AND DEVELOPMENTAL STAGE.
RX PubMed=8808402; DOI=10.1016/0925-4773(95)00455-6;
RA van der Hoeven F., Sordino P., Fraudeau N., Izpisua-Belmonte J.-C.,
RA Duboule D.;
RT "Teleost HoxD and HoxA genes: comparison with tetrapods and functional
RT evolution of the HOXD complex.";
RL Mech. Dev. 54:9-21(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 109-210.
RC STRAIN=Tuebingen;
RX PubMed=16174031; DOI=10.1111/j.1525-142x.2005.05042.x;
RA Corredor-Adamez M., Welten M.C.M., Spaink H.P., Jeffery J.E., Schoon R.T.,
RA de Bakker M.A.G., Bagowski C.P., Meijer A.H., Verbeek F.J.,
RA Richardson M.K.;
RT "Genomic annotation and transcriptome analysis of the zebrafish (Danio
RT rerio) hox complex with description of a novel member, hoxb13a.";
RL Evol. Dev. 7:362-375(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 227-276.
RC TISSUE=Embryo;
RX PubMed=9425136; DOI=10.1242/dev.125.3.407;
RA Prince V.E., Joly L., Ekker M., Ho R.K.;
RT "Zebrafish hox genes: genomic organization and modified colinear expression
RT patterns in the trunk.";
RL Development 125:407-420(1998).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- DEVELOPMENTAL STAGE: First expressed at 12 hours post-fertilization
CC (hpf) in the dorsal pre-somitic mesoderm and neural keel at posterior
CC levels, extending into the ventral somitic mesoderm during budding. At
CC 22-26 hpf, expression decreases in the lateral and ventral mesoderm,
CC but is maintained in the neural rod. Expression decreases from
CC posterior to anterior with an anterior expression limit at somite 11.
CC At 24-26 hpf, posterior expression begin to weaken and is undetectable
CC by 40-56 hpf. {ECO:0000269|PubMed:8808402}.
CC -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI14272.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAA74878.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305};
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DR EMBL; BC114271; AAI14272.1; ALT_INIT; mRNA.
DR EMBL; X87751; CAA61030.1; -; Genomic_DNA.
DR EMBL; DQ069272; AAY87054.1; -; mRNA.
DR EMBL; Y14543; CAA74878.1; ALT_SEQ; mRNA.
DR RefSeq; NP_571242.1; NM_131167.1.
DR AlphaFoldDB; Q90470; -.
DR SMR; Q90470; -.
DR STRING; 7955.ENSDARP00000076780; -.
DR PaxDb; Q90470; -.
DR DNASU; 30405; -.
DR Ensembl; ENSDART00000082344; ENSDARP00000076780; ENSDARG00000059267.
DR GeneID; 30405; -.
DR KEGG; dre:30405; -.
DR CTD; 30405; -.
DR ZFIN; ZDB-GENE-990415-117; hoxd11a.
DR eggNOG; KOG0487; Eukaryota.
DR GeneTree; ENSGT00940000161308; -.
DR HOGENOM; CLU_079662_0_0_1; -.
DR InParanoid; Q90470; -.
DR OMA; YYSTDEI; -.
DR OrthoDB; 976319at2759; -.
DR PhylomeDB; Q90470; -.
DR TreeFam; TF350668; -.
DR PRO; PR:Q90470; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 9.
DR Bgee; ENSDARG00000059267; Expressed in presomitic mesoderm and 14 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR021918; DUF3528.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF12045; DUF3528; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..276
FT /note="Homeobox protein Hox-D11a"
FT /id="PRO_0000200234"
FT DNA_BIND 204..263
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 139..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 229
FT /note="I -> M (in Ref. 4)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 276 AA; 32046 MW; 3BA87811125F0088 CRC64;
MTDYDDRNNC ASNMYLPYYV STPDFSSVSS FLPQTTSCQV NFPYSSNIAQ VQPVREVTFR
DYGLDHPSKW HYRGNYASYY STEEIMHRDL LQSTNRAEMI FKNDSMYSHH AGTNSSCSFF
TNVGRNGVLP QGFDQFFETA NSEKPNPEQS KQKPDTSVPG DAACNPSTDS AEQTKQDPTD
TVEEESSVST CDEEKNSGSS ATKSRKKRCP YSKYQIRELE REFFFNVYIN KEKRLQLSRM
LSLTDRQVKI WFQNRRMKEK KLNRDRLQYF TGNPLF
