ID   HXDCA_DANRE             Reviewed;         262 AA.
AC   Q90471; O57373; Q4JMC8;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 2.
DT   03-AUG-2022, entry version 154.
DE   RecName: Full=Homeobox protein Hox-D12a;
DE            Short=Hox-D12;
GN   Name=hoxd12a; Synonyms=hox-d12, hoxd12;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DEVELOPMENTAL STAGE.
RX   PubMed=8808402; DOI=10.1016/0925-4773(95)00455-6;
RA   van der Hoeven F., Sordino P., Fraudeau N., Izpisua-Belmonte J.-C.,
RA   Duboule D.;
RT   "Teleost HoxD and HoxA genes: comparison with tetrapods and functional
RT   evolution of the HOXD complex.";
RL   Mech. Dev. 54:9-21(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 73-204.
RC   STRAIN=Tuebingen;
RX   PubMed=16174031; DOI=10.1111/j.1525-142x.2005.05042.x;
RA   Corredor-Adamez M., Welten M.C.M., Spaink H.P., Jeffery J.E., Schoon R.T.,
RA   de Bakker M.A.G., Bagowski C.P., Meijer A.H., Verbeek F.J.,
RA   Richardson M.K.;
RT   "Genomic annotation and transcriptome analysis of the zebrafish (Danio
RT   rerio) hox complex with description of a novel member, hoxb13a.";
RL   Evol. Dev. 7:362-375(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 216-262.
RC   TISSUE=Embryo;
RX   PubMed=9425136; DOI=10.1242/dev.125.3.407;
RA   Prince V.E., Joly L., Ekker M., Ho R.K.;
RT   "Zebrafish hox genes: genomic organization and modified colinear expression
RT   patterns in the trunk.";
RL   Development 125:407-420(1998).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DEVELOPMENTAL STAGE: First expressed at 14 hours post-fertilization
CC       (hpf) in the dorsal pre-somitic mesoderm and neural keel at posterior
CC       levels, extending into the ventral somitic mesoderm during budding. At
CC       22-26 hpf, expression decreases in the lateral and ventral mesoderm,
CC       but is maintained in the neural rod. Expression decreases from
CC       posterior to anterior with an anterior expression limit at somite 17.
CC       Also expressed in the developing hindgut, except in the most distal
CC       portion. At 24-26 hpf, posterior expression begin to weaken and is
CC       undetectable by 40-56 hpf. {ECO:0000269|PubMed:8808402}.
CC   -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA61032.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=CAA61032.1; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=CAA74882.1; Type=Frameshift; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X87753; CAA61032.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; DQ069273; AAY87055.1; -; mRNA.
DR   EMBL; Y14547; CAA74882.1; ALT_FRAME; mRNA.
DR   RefSeq; XP_005172570.1; XM_005172513.3.
DR   AlphaFoldDB; Q90471; -.
DR   SMR; Q90471; -.
DR   STRING; 7955.ENSDARP00000076775; -.
DR   Ensembl; ENSDART00000142842; ENSDARP00000121699; ENSDARG00000059263.
DR   GeneID; 100006598; -.
DR   CTD; 100006598; -.
DR   ZFIN; ZDB-GENE-990415-118; hoxd12a.
DR   eggNOG; KOG0487; Eukaryota.
DR   GeneTree; ENSGT00940000159938; -.
DR   InParanoid; Q90471; -.
DR   OMA; FAQGAPW; -.
DR   PhylomeDB; Q90471; -.
DR   PRO; PR:Q90471; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 9.
DR   Bgee; ENSDARG00000059263; Expressed in tail bud paraxial mesoderm and 17 other tissues.
DR   ExpressionAtlas; Q90471; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..262
FT                   /note="Homeobox protein Hox-D12a"
FT                   /id="PRO_0000200241"
FT   DNA_BIND        194..253
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          107..130
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        219..220
FT                   /note="IN -> MT (in Ref. 3)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   262 AA;  29739 MW;  151D52E1DCB8802A CRC64;
     MCEHNLLSSG YVAPLLNFHS PDSLYLQNLR GNGVHLSGLP QMSYSRREVC SLPWSSSNSC
     TAPAQSRAYS GYSQPFFSNS AAVSASLNTH KKGSLEESGR YYFQDVSHKS EEPGRPNAAY
     ASEQSSASNG LSNLERRQLN AVAPNELSCI EQPESDASKQ SVSSIAPFQP SLSAQNIRPA
     FTDGLPWCPS QVRSRKKRKP YTKPQLTELE NEFMMNEFIN RQKRKELSDR LELSDQQVKI
     WFQNRRMKKK RLMMREHTFT IY