ID   HXDDA_DANRE             Reviewed;         256 AA.
AC   Q90472; Q58EB3;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 2.
DT   03-AUG-2022, entry version 147.
DE   RecName: Full=Homeobox protein Hox-D13a;
DE            Short=Hox-D13;
GN   Name=hoxd13a; Synonyms=hoxd-13, hoxd13; ORFNames=zgc:110511;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DEVELOPMENTAL STAGE.
RX   PubMed=8808402; DOI=10.1016/0925-4773(95)00455-6;
RA   van der Hoeven F., Sordino P., Fraudeau N., Izpisua-Belmonte J.-C.,
RA   Duboule D.;
RT   "Teleost HoxD and HoxA genes: comparison with tetrapods and functional
RT   evolution of the HOXD complex.";
RL   Mech. Dev. 54:9-21(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DEVELOPMENTAL STAGE: First expressed at 15 hours post-fertilization
CC       (hpf) in the presumptive proctodeum. At 22 hpf, expressed in the most
CC       distal part of the hindgut, the future rectum and the cloacal region;
CC       cloacal expression is still detectable until 64 hpf. First detected in
CC       the dorsal pre-somitic mesoderm and neural keel at 17 hpf. At 22-26
CC       hpf, expression is restricted to the posterior tip of the trunk, begins
CC       to weaken and is undetectable by 40-56 hpf.
CC       {ECO:0000269|PubMed:8808402}.
CC   -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
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DR   EMBL; X87752; CAA61031.1; -; Genomic_DNA.
DR   EMBL; BC091996; AAH91996.1; -; mRNA.
DR   RefSeq; NP_571244.2; NM_131169.3.
DR   AlphaFoldDB; Q90472; -.
DR   SMR; Q90472; -.
DR   STRING; 7955.ENSDARP00000076768; -.
DR   PaxDb; Q90472; -.
DR   Ensembl; ENSDART00000082332; ENSDARP00000076768; ENSDARG00000059256.
DR   GeneID; 30407; -.
DR   KEGG; dre:30407; -.
DR   CTD; 30407; -.
DR   ZFIN; ZDB-GENE-990415-119; hoxd13a.
DR   eggNOG; KOG0487; Eukaryota.
DR   GeneTree; ENSGT00940000164071; -.
DR   HOGENOM; CLU_059940_2_0_1; -.
DR   InParanoid; Q90472; -.
DR   OMA; EREYTIC; -.
DR   OrthoDB; 1190384at2759; -.
DR   PhylomeDB; Q90472; -.
DR   TreeFam; TF330813; -.
DR   PRO; PR:Q90472; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 9.
DR   Bgee; ENSDARG00000059256; Expressed in mesenchyme pectoral fin and 12 other tissues.
DR   ExpressionAtlas; Q90472; baseline.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..256
FT                   /note="Homeobox protein Hox-D13a"
FT                   /id="PRO_0000200247"
FT   DNA_BIND        191..250
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   CONFLICT        15
FT                   /note="P -> A (in Ref. 1; CAA61031)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        46
FT                   /note="I -> V (in Ref. 1; CAA61031)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        115
FT                   /note="R -> G (in Ref. 1; CAA61031)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        137
FT                   /note="L -> R (in Ref. 1; CAA61031)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        164
FT                   /note="F -> S (in Ref. 1; CAA61031)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   256 AA;  29113 MW;  C3760018B155F861 CRC64;
     MDGGGLDEEF INVYPSAFGT HSSRCTSGAP VLSAVDRPTS VCNESISPYF SFPSNIGSGS
     FTFGCHLENS YKVPQNAVFP PGVAKQNGQF ANKPVDHGEA SSWLKEFAFY QGCARSYPRI
     PAFIDLPVVQ RAMMGDLRHE TCLTMEGHQH WDWSNNCSSQ LYCFQDQTRS PHIWKPSLTE
     EAAAASFCQR GRKKRVPYTK FQLKELEREY NTTKFITKEN RRRIASSTNL SERQVTIWFQ
     NRRVKDKKRP DVCIKC