HXK_PLAFA
ID HXK_PLAFA Reviewed; 493 AA.
AC Q02155;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1993, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Hexokinase;
DE EC=2.7.1.1 {ECO:0000250|UniProtKB:A0A0K0JFP3};
GN Name=HK;
OS Plasmodium falciparum.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=5833;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1475005; DOI=10.1016/0166-6851(92)90157-f;
RA Olafsson P., Matile H., Cesta U.;
RT "Molecular analysis of Plasmodium falciparum hexokinase.";
RL Mol. Biochem. Parasitol. 56:89-102(1992).
CC -!- FUNCTION: Catalyzes the phosphorylation of various hexoses to hexose 6-
CC phosphate. {ECO:0000250|UniProtKB:A0A0K0JFP3}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-hexose = ADP + D-hexose 6-phosphate + H(+);
CC Xref=Rhea:RHEA:22740, ChEBI:CHEBI:4194, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61567, ChEBI:CHEBI:456216; EC=2.7.1.1;
CC Evidence={ECO:0000250|UniProtKB:A0A0K0JFP3, ECO:0000255|PROSITE-
CC ProRule:PRU01084};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22741;
CC Evidence={ECO:0000250|UniProtKB:A0A0K0JFP3};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-mannose = ADP + D-mannose 6-phosphate + H(+);
CC Xref=Rhea:RHEA:11028, ChEBI:CHEBI:4208, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:58735, ChEBI:CHEBI:456216; EC=2.7.1.1;
CC Evidence={ECO:0000250|UniProtKB:A0A0K0JFP3};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11029;
CC Evidence={ECO:0000250|UniProtKB:A0A0K0JFP3};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+);
CC Xref=Rhea:RHEA:16125, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:37721, ChEBI:CHEBI:61527, ChEBI:CHEBI:456216; EC=2.7.1.1;
CC Evidence={ECO:0000250|UniProtKB:A0A0K0JFP3};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16126;
CC Evidence={ECO:0000250|UniProtKB:A0A0K0JFP3};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+);
CC Xref=Rhea:RHEA:17825, ChEBI:CHEBI:4167, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61548, ChEBI:CHEBI:456216; EC=2.7.1.1;
CC Evidence={ECO:0000250|UniProtKB:A0A0K0JFP3};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17826;
CC Evidence={ECO:0000250|UniProtKB:A0A0K0JFP3};
CC -!- PATHWAY: Carbohydrate metabolism; hexose metabolism.
CC {ECO:0000250|UniProtKB:A0A0K0JFP3}.
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC phosphate and glycerone phosphate from D-glucose: step 1/4.
CC {ECO:0000250|UniProtKB:A0A0K0JFP3}.
CC -!- SIMILARITY: Belongs to the hexokinase family. {ECO:0000255|PROSITE-
CC ProRule:PRU01084, ECO:0000305}.
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DR EMBL; M92054; AAA29613.1; -; Genomic_DNA.
DR PIR; A48457; A48457.
DR AlphaFoldDB; Q02155; -.
DR SMR; Q02155; -.
DR DrugBank; DB11638; Artenimol.
DR VEuPathDB; PlasmoDB:PF3D7_0624000; -.
DR VEuPathDB; PlasmoDB:Pf7G8-2_000176400; -.
DR VEuPathDB; PlasmoDB:Pf7G8_060029000; -.
DR VEuPathDB; PlasmoDB:PfCD01_060029400; -.
DR VEuPathDB; PlasmoDB:PfDd2_060028700; -.
DR VEuPathDB; PlasmoDB:PfGA01_060029000; -.
DR VEuPathDB; PlasmoDB:PfGB4_060028500; -.
DR VEuPathDB; PlasmoDB:PfGN01_060029700; -.
DR VEuPathDB; PlasmoDB:PfHB3_060028200; -.
DR VEuPathDB; PlasmoDB:PfIT_060027800; -.
DR VEuPathDB; PlasmoDB:PfKE01_060030100; -.
DR VEuPathDB; PlasmoDB:PfKH01_060031000; -.
DR VEuPathDB; PlasmoDB:PfKH02_060030500; -.
DR VEuPathDB; PlasmoDB:PfML01_060027800; -.
DR VEuPathDB; PlasmoDB:PfNF135_060028200; -.
DR VEuPathDB; PlasmoDB:PfNF166_060028500; -.
DR VEuPathDB; PlasmoDB:PfNF54_060029000; -.
DR VEuPathDB; PlasmoDB:PfSD01_060027900; -.
DR VEuPathDB; PlasmoDB:PfSN01_060028900; -.
DR VEuPathDB; PlasmoDB:PfTG01_060029300; -.
DR BRENDA; 2.7.1.1; 4889.
DR SABIO-RK; Q02155; -.
DR UniPathway; UPA00109; UER00180.
DR UniPathway; UPA00242; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008865; F:fructokinase activity; IEA:RHEA.
DR GO; GO:0004340; F:glucokinase activity; IEA:RHEA.
DR GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR GO; GO:0019158; F:mannokinase activity; IEA:RHEA.
DR GO; GO:0001678; P:cellular glucose homeostasis; IEA:InterPro.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0019318; P:hexose metabolic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR001312; Hexokinase.
DR InterPro; IPR019807; Hexokinase_BS.
DR InterPro; IPR022673; Hexokinase_C.
DR InterPro; IPR022672; Hexokinase_N.
DR PANTHER; PTHR19443; PTHR19443; 1.
DR Pfam; PF00349; Hexokinase_1; 1.
DR Pfam; PF03727; Hexokinase_2; 1.
DR SUPFAM; SSF53067; SSF53067; 2.
DR PROSITE; PS00378; HEXOKINASE_1; 1.
DR PROSITE; PS51748; HEXOKINASE_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Glycolysis; Kinase; Nucleotide-binding; Transferase.
FT CHAIN 1..493
FT /note="Hexokinase"
FT /id="PRO_0000197598"
FT DOMAIN 27..481
FT /note="Hexokinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01084"
FT REGION 91..239
FT /note="Hexokinase small subdomain"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01084"
FT REGION 177..203
FT /note="Glucose-binding"
FT /evidence="ECO:0000255"
FT REGION 240..470
FT /note="Hexokinase large subdomain"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01084"
FT BINDING 102..107
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 493 AA; 55346 MW; 6EE843FB0E1A3F3F CRC64;
MSEYDIAKND VTYTKLDTIE CDIPINEELS WRINKFVNQL RISYSTLEEF VDNFVYELKK
GLEAHRKHPN LWIPHECSFK MLDSCIANIP TGQEKGTYYA IDFGGTNFRA VRASLDGKGK
IKRDQETYSL KFTGSYSHEK GLLDKHATAS QLFDHFAERI KYIMGEFNDL DNKEVKSVGF
TFSFPCTSPS INCSILIDWT KGFETGRATN DPVEGRDVCK LMNDAFVRAA IPAKVCCVLN
DAVGTLMSCA YQKGRGTPPC YIGIILGTGS NGCYYEPEWK KYKYAGKIIN IEFGNFDKDL
PTSPIDLVMD WYSANRSRQL FEKMISGAYL GEIVRRFMVN VLQSACSKKM WISDSFNSES
GSVVLNDTSK NFEDSRKVAK AAWDMDFTDE QIYVLRKICE AVYNRSAALA RGTIAAIAKR
IKIIEHSKFT CGVDGSLFVK NAWYCKRLQE HLKVILADKA ENLIIIPADD GSGKGAAITA
AVIALNADIP QLP
