HXLR_BACSU
ID HXLR_BACSU Reviewed; 120 AA.
AC P42406; O31478;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 16-JUN-2009, sequence version 3.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=HTH-type transcriptional activator HxlR;
GN Name=hxlR; OrderedLocusNames=BSU03470;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=7704255; DOI=10.1099/13500872-141-2-277;
RA Fujishima Y., Yamane K.;
RT "A 10 kb nucleotide sequence at the 5' flanking region (32 degrees) of
RT srfAA of the Bacillus subtilis chromosome.";
RL Microbiology 141:277-279(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=8969502; DOI=10.1099/13500872-142-11-3047;
RA Yamane K., Kumano M., Kurita K.;
RT "The 25 degrees-36 degrees region of the Bacillus subtilis chromosome:
RT determination of the sequence of a 146 kb segment and identification of 113
RT genes.";
RL Microbiology 142:3047-3056(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [4]
RP SEQUENCE REVISION TO 62.
RX PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT 168 reference genome a decade later.";
RL Microbiology 155:1758-1775(2009).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 111-120.
RX PubMed=1715856; DOI=10.1128/jb.173.17.5487-5493.1991;
RA Nakano M.M., Xia L., Zuber P.;
RT "Transcription initiation region of the srfA operon, which is controlled by
RT the comP-comA signal transduction system in Bacillus subtilis.";
RL J. Bacteriol. 173:5487-5493(1991).
RN [6]
RP CHARACTERIZATION.
RC STRAIN=168;
RX PubMed=10572115; DOI=10.1128/jb.181.23.7154-7160.1999;
RA Yasueda H., Kawahara Y., Sugimoto S.;
RT "Bacillus subtilis yckG and yckF encode two key enzymes of the ribulose
RT monophosphate pathway used by methylotrophs, and yckH is required for their
RT expression.";
RL J. Bacteriol. 181:7154-7160(1999).
CC -!- FUNCTION: Positive regulator of hxlAB expression.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA06435.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAA08981.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; D30762; BAA06435.1; ALT_INIT; Genomic_DNA.
DR EMBL; D50453; BAA08981.1; ALT_INIT; Genomic_DNA.
DR EMBL; AL009126; CAB12141.2; -; Genomic_DNA.
DR EMBL; M64702; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; B69761; B69761.
DR RefSeq; NP_388229.2; NC_000964.3.
DR RefSeq; WP_003246265.1; NZ_JNCM01000030.1.
DR PDB; 7BZD; X-ray; 2.61 A; A=1-120.
DR PDB; 7BZE; X-ray; 1.66 A; A=1-120.
DR PDB; 7BZG; X-ray; 2.90 A; A/B/E/F/I/J=1-120.
DR PDBsum; 7BZD; -.
DR PDBsum; 7BZE; -.
DR PDBsum; 7BZG; -.
DR AlphaFoldDB; P42406; -.
DR SMR; P42406; -.
DR STRING; 224308.BSU03470; -.
DR PaxDb; P42406; -.
DR PRIDE; P42406; -.
DR DNASU; 938311; -.
DR EnsemblBacteria; CAB12141; CAB12141; BSU_03470.
DR GeneID; 938311; -.
DR KEGG; bsu:BSU03470; -.
DR PATRIC; fig|224308.179.peg.364; -.
DR eggNOG; COG1733; Bacteria.
DR InParanoid; P42406; -.
DR OMA; MYDWGKD; -.
DR PhylomeDB; P42406; -.
DR BioCyc; BSUB:BSU03470-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR002577; HTH_HxlR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF01638; HxlR; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS51118; HTH_HXLR; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Activator; DNA-binding; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..120
FT /note="HTH-type transcriptional activator HxlR"
FT /id="PRO_0000148879"
FT DOMAIN 11..110
FT /note="HTH hxlR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00435"
FT CONFLICT 62
FT /note="L -> R (in Ref. 1; BAA06435 and 2; BAA08981)"
FT /evidence="ECO:0000305"
FT HELIX 3..5
FT /evidence="ECO:0007829|PDB:7BZG"
FT HELIX 6..20
FT /evidence="ECO:0007829|PDB:7BZE"
FT STRAND 22..24
FT /evidence="ECO:0007829|PDB:7BZE"
FT HELIX 25..35
FT /evidence="ECO:0007829|PDB:7BZE"
FT STRAND 37..39
FT /evidence="ECO:0007829|PDB:7BZD"
FT HELIX 40..46
FT /evidence="ECO:0007829|PDB:7BZE"
FT HELIX 52..64
FT /evidence="ECO:0007829|PDB:7BZE"
FT STRAND 67..73
FT /evidence="ECO:0007829|PDB:7BZE"
FT STRAND 75..77
FT /evidence="ECO:0007829|PDB:7BZE"
FT STRAND 79..84
FT /evidence="ECO:0007829|PDB:7BZE"
FT HELIX 86..89
FT /evidence="ECO:0007829|PDB:7BZE"
FT HELIX 92..111
FT /evidence="ECO:0007829|PDB:7BZE"
SQ SEQUENCE 120 AA; 14104 MW; C53CCB6E84BAE8AF CRC64;
MSRMDDKRFN CEKELTLAVI GGKWKMLILW HLGKEGTKRF NELKTLIPDI TQKILVNQLR
ELEQDMIVHR EVYPVVPPKV EYSLTPHGES LMPILEAMYE WGKGYMELID IDKNVMKESL
