ID   HXNT_EMENI              Reviewed;         388 AA.
AC   A0A1U8QTA2; C8VJV9; Q5ARA3;
DT   28-FEB-2018, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2017, sequence version 1.
DT   25-MAY-2022, entry version 19.
DE   RecName: Full=Flavin oxidoreductase hxnT {ECO:0000303|PubMed:29212709};
DE            EC=1.-.-.- {ECO:0000305|PubMed:29212709};
DE   AltName: Full=Nicotinate catabolism cluster protein hxnS {ECO:0000303|PubMed:29212709};
GN   Name=hxnT {ECO:0000303|PubMed:29212709}; ORFNames=ANIA_9177;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS   M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Nidulantes.
OX   NCBI_TaxID=227321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA   Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA   Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA   Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA   Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA   Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA   Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA   Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA   Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA   Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA   Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA   Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA   Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA   van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA   Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA   Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA   Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA   Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA   Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA   van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA   Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA   Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT   effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
RN   [3]
RP   IDENTIFICATION, INDUCTION, FUNCTION, AND COFACTOR.
RX   PubMed=29212709; DOI=10.1098/rsob.170199;
RA   Amon J., Fernandez-Martin R., Bokor E., Cultrone A., Kelly J.M.,
RA   Flipphi M., Scazzocchio C., Hamari Z.;
RT   "A eukaryotic nicotinate-inducible gene cluster: convergent evolution in
RT   fungi and bacteria.";
RL   Open Biol. 7:0-0(2017).
CC   -!- FUNCTION: Flavin oxidoreductase, part of the hnx cluster involved in
CC       the purine degradation (PubMed:29212709). The nicotinate hydroxylase
CC       hnxS accepts nicotinate as a substrate and catalyzes the first step of
CC       nicotinate catabolism (PubMed:29212709). The major facilitator-type
CC       transporters hxnP and hxnZ are probably involved in the uptake of
CC       nicotinate-derived metabolites, and the oxidoreductases hxnT and hxnY
CC       in the further metabolism of 6-OH nicotinic acid (PubMed:29212709).
CC       {ECO:0000269|PubMed:29212709}.
CC   -!- COFACTOR:
CC       Name=FMN; Xref=ChEBI:CHEBI:58210;
CC         Evidence={ECO:0000305|PubMed:29212709};
CC   -!- INDUCTION: Expression is induced by nicotinate and 6-OH nicotinate,
CC       subject to nitrogen metabolite repression mediated by the GATA factor
CC       areA, and strictly regulated by the cluster-specific transcription
CC       regulator hnxR (PubMed:29212709). {ECO:0000269|PubMed:29212709}.
CC   -!- SIMILARITY: Belongs to the NADH:flavin oxidoreductase/NADH oxidase
CC       family. {ECO:0000305}.
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DR   EMBL; AACD01000170; EAA61468.1; -; Genomic_DNA.
DR   EMBL; BN001306; CBF82381.1; -; Genomic_DNA.
DR   RefSeq; XP_682446.1; XM_677354.1.
DR   AlphaFoldDB; A0A1U8QTA2; -.
DR   SMR; A0A1U8QTA2; -.
DR   STRING; 162425.CADANIAP00009420; -.
DR   EnsemblFungi; CBF82381; CBF82381; ANIA_09177.
DR   EnsemblFungi; EAA61468; EAA61468; AN9177.2.
DR   GeneID; 2868055; -.
DR   KEGG; ani:AN9177.2; -.
DR   VEuPathDB; FungiDB:AN9177; -.
DR   eggNOG; KOG0134; Eukaryota.
DR   OMA; RWFIANP; -.
DR   OrthoDB; 978998at2759; -.
DR   Proteomes; UP000000560; Chromosome VI.
DR   Proteomes; UP000005890; Unassembled WGS sequence.
DR   GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR001155; OxRdtase_FMN_N.
DR   InterPro; IPR045247; Oye-like.
DR   PANTHER; PTHR22893; PTHR22893; 1.
DR   Pfam; PF00724; Oxidored_FMN; 1.
PE   2: Evidence at transcript level;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..388
FT                   /note="Flavin oxidoreductase hxnT"
FT                   /id="PRO_0000443340"
SQ   SEQUENCE   388 AA;  42404 MW;  AE7902158E1AB8A2 CRC64;
     MGSLSPLEPL FTPLRIGAFA LQHRVVQAPC TRMRSTKESD GIWVPNDLNV EYYAQRASKG
     GLMLSEATPI SRDAAGYPGV PGIFTPSQIE GWRKVTNAVH TKGGLILCQL WHVGRATTPG
     FLGGKTPLAP SDIPISGKAL DGNVYADAPP RPMTVDEIKE VVLEYAAASK RAIEAGFDGV
     EIHGGNGYLL DQFLHDNVNN RTDAYGGSIE NRSRIVLEII SAVTEAIGAE RVGIRLSPYN
     YFQDTRDSNP QKHWGYLCTQ IASLPESSRP AYVHMIEPRF DEILDESEKI SALETMQEVV
     KPSLDGLRSS LKKGGVSFIA AGNFKPENAG EKLITDSADA IAFGRLFISN PDLPRRLKEG
     IELTKYDRST FYGATPPEKG YTDYPFAQ