HXT10_YEAST
ID HXT10_YEAST Reviewed; 546 AA.
AC P43581; D6VTL8;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 178.
DE RecName: Full=Hexose transporter HXT10;
GN Name=HXT10; OrderedLocusNames=YFL011W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7670463; DOI=10.1038/ng0795-261;
RA Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S.,
RA Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H.,
RA Eki T.;
RT "Analysis of the nucleotide sequence of chromosome VI from Saccharomyces
RT cerevisiae.";
RL Nat. Genet. 10:261-268(1995).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204511 / S288c / AB972;
RA Barrell B.G., Churcher C., Rajandream M.A.;
RL Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA Kim H., Melen K., Oesterberg M., von Heijne G.;
RT "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
CC -!- FUNCTION: Probable glucose transporter.
CC -!- INTERACTION:
CC P43581; P02829: HSP82; NbExp=2; IntAct=EBI-8750, EBI-8659;
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
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DR EMBL; D50617; BAA09227.1; -; Genomic_DNA.
DR EMBL; Z46255; CAA86344.1; -; Genomic_DNA.
DR EMBL; BK006940; DAA12428.1; -; Genomic_DNA.
DR PIR; S48313; S48313.
DR RefSeq; NP_116644.1; NM_001179955.1.
DR AlphaFoldDB; P43581; -.
DR SMR; P43581; -.
DR BioGRID; 31135; 64.
DR DIP; DIP-5424N; -.
DR IntAct; P43581; 1.
DR STRING; 4932.YFL011W; -.
DR TCDB; 2.A.1.1.5; the major facilitator superfamily (mfs).
DR iPTMnet; P43581; -.
DR PaxDb; P43581; -.
DR PRIDE; P43581; -.
DR EnsemblFungi; YFL011W_mRNA; YFL011W; YFL011W.
DR GeneID; 850536; -.
DR KEGG; sce:YFL011W; -.
DR SGD; S000001883; HXT10.
DR VEuPathDB; FungiDB:YFL011W; -.
DR eggNOG; KOG0254; Eukaryota.
DR GeneTree; ENSGT00940000176280; -.
DR HOGENOM; CLU_001265_30_1_1; -.
DR InParanoid; P43581; -.
DR OMA; AIVCCYQ; -.
DR BioCyc; YEAST:G3O-30445-MON; -.
DR PRO; PR:P43581; -.
DR Proteomes; UP000002311; Chromosome VI.
DR RNAct; P43581; protein.
DR GO; GO:0071944; C:cell periphery; HDA:SGD.
DR GO; GO:0000324; C:fungal-type vacuole; HDA:SGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005351; F:carbohydrate:proton symporter activity; IBA:GO_Central.
DR GO; GO:0005353; F:fructose transmembrane transporter activity; IMP:SGD.
DR GO; GO:0005354; F:galactose transmembrane transporter activity; IMP:SGD.
DR GO; GO:0005355; F:glucose transmembrane transporter activity; IMP:SGD.
DR GO; GO:0015578; F:mannose transmembrane transporter activity; IMP:SGD.
DR GO; GO:0008643; P:carbohydrate transport; IBA:GO_Central.
DR GO; GO:0008645; P:hexose transmembrane transport; IMP:SGD.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00879; SP; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Reference proteome; Repeat; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..546
FT /note="Hexose transporter HXT10"
FT /id="PRO_0000050400"
FT TOPO_DOM 1..44
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 45..65
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 66..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..127
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..148
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 149..158
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 180..185
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 186..206
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 207..220
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 221..241
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 242..324
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 325..341
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 342..347
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 348..365
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 366..372
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 373..393
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 394..415
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 416..436
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 437..453
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 454..474
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 475
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 476..496
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 497..546
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 75
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 546 AA; 60662 MW; B2D80CDBBECC398F CRC64;
MVSSSVSILG TSAKASTSLS RKDEIKLTPE TREASLDIPY KPIIAYWTVM GLCLMIAFGG
FIFGWDTGTI SGFINQTDFK RRFGELQRDG SFQLSDVRTG LIVGIFNIGC ALGGLTLGRL
GDIYGRKIGL MCVILVYVVG IVIQIASSDK WYQYFIGRIV SGMGVGGVAV LSPTLISEIS
PKHLRGTCVS FYQLMITLGI FLGYCTNYGT KKYSNSIQWR VPLGLCFAWA IFMVIGMVMV
PESPRYLVEK GKYEEARRSL AKSNKVTVTD PGVVFEFDTI VANMELERAV GNASWHELFS
NKGAILPRVI MGIVIQSLQQ LTGCNYFFYY GTTIFNAVGM QDSFETSIVL GAVNFASTFV
ALYIVDKFGR RKCLLWGSAS MAICFVIFAT VGVTRLWPQG KDQPSSQSAG NVMIVFTCFF
IFSFAITWAP IAYVIVAETY PLRVKNRAMA IAVGANWMWG FLIGFFTPFI TRSIGFSYGY
VFMGCLIFSY FYVFFFVCET KGLTLEEVNE MYEERIKPWK SGGWIPSSRR TPQPTSSTPL
VIVDSK
