HXT11_YEAST
ID HXT11_YEAST Reviewed; 567 AA.
AC P54862; D6W1R4;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 167.
DE RecName: Full=Hexose transporter HXT11;
DE AltName: Full=Low-affinity glucose transporter LGT3;
GN Name=HXT11; Synonyms=LGT3; OrderedLocusNames=YOL156W;
GN ORFNames=AOB567, O0414;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Wesolowski-Louvel M.;
RL Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 96604 / S288c / FY1679;
RX PubMed=8810044;
RX DOI=10.1002/(sici)1097-0061(19960615)12:7<709::aid-yea957>3.0.co;2-1;
RA Gamo F.-J., Lafuente M.J., Casamayor A., Arino J., Aldea M., Casas C.,
RA Herrero E., Gancedo C.;
RT "Analysis of the DNA sequence of a 15,500 bp fragment near the left
RT telomere of chromosome XV from Saccharomyces cerevisiae reveals a putative
RT sugar transporter, a carboxypeptidase homologue and two new open reading
RT frames.";
RL Yeast 12:709-714(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169874;
RA Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J.,
RA Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A.,
RA Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B.,
RA Dang V.-D., de Haan M., Delius H., Durand P., Fairhead C., Feldmann H.,
RA Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E.,
RA Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U.,
RA Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B.,
RA Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A.,
RA Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C.,
RA Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G.,
RA Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B.,
RA Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B.,
RA Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F.,
RA Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E.,
RA Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I.,
RA Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H.,
RA Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.";
RL Nature 387:98-102(1997).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [5]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA Kim H., Melen K., Oesterberg M., von Heijne G.;
RT "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
CC -!- FUNCTION: Probable glucose transporter.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
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DR EMBL; X82621; CAA57942.1; -; Genomic_DNA.
DR EMBL; X89715; CAA61859.1; -; Genomic_DNA.
DR EMBL; Z74898; CAA99178.1; -; Genomic_DNA.
DR EMBL; BK006948; DAA10630.1; -; Genomic_DNA.
DR PIR; S49600; S49600.
DR RefSeq; NP_014486.1; NM_001183409.1.
DR AlphaFoldDB; P54862; -.
DR SMR; P54862; -.
DR BioGRID; 34262; 30.
DR DIP; DIP-4071N; -.
DR IntAct; P54862; 3.
DR MINT; P54862; -.
DR STRING; 4932.YOL156W; -.
DR TCDB; 2.A.1.1.105; the major facilitator superfamily (mfs).
DR PaxDb; P54862; -.
DR EnsemblFungi; YOL156W_mRNA; YOL156W; YOL156W.
DR GeneID; 854009; -.
DR KEGG; sce:YOL156W; -.
DR SGD; S000005516; HXT11.
DR VEuPathDB; FungiDB:YOL156W; -.
DR eggNOG; KOG0254; Eukaryota.
DR GeneTree; ENSGT00940000176280; -.
DR HOGENOM; CLU_001265_30_1_1; -.
DR InParanoid; P54862; -.
DR OMA; PHENDIE; -.
DR BioCyc; YEAST:G3O-33544-MON; -.
DR ChiTaRS; HXT11; yeast.
DR PRO; PR:P54862; -.
DR Proteomes; UP000002311; Chromosome XV.
DR RNAct; P54862; protein.
DR GO; GO:0071944; C:cell periphery; HDA:SGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005351; F:carbohydrate:proton symporter activity; IBA:GO_Central.
DR GO; GO:0005353; F:fructose transmembrane transporter activity; IMP:SGD.
DR GO; GO:0005354; F:galactose transmembrane transporter activity; IMP:SGD.
DR GO; GO:0005355; F:glucose transmembrane transporter activity; IMP:SGD.
DR GO; GO:0015578; F:mannose transmembrane transporter activity; IMP:SGD.
DR GO; GO:0008643; P:carbohydrate transport; IBA:GO_Central.
DR GO; GO:0008645; P:hexose transmembrane transport; IMP:SGD.
DR GO; GO:1902341; P:xylitol transmembrane transport; IGI:SGD.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00879; SP; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Reference proteome; Repeat; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..567
FT /note="Hexose transporter HXT11"
FT /id="PRO_0000050401"
FT TOPO_DOM 1..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..112
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 134..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..170
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 192..197
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..232
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 254..336
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 337..353
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 354..359
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 360..377
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 378..384
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 385..405
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 406..429
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 430..450
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 451..467
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 468..488
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 489
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 490..510
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 511..567
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..42
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 87
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 227
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 567 AA; 62733 MW; 3A86EC9AC954DBB2 CRC64;
MSGVNNTSAN ELSTTMSNSN SAVGAPSVKT EHGDSKNSLN LDANEPPIDL PQKPLSAYTT
VAILCLMIAF GGFIFGWDTG TISGFVNLSD FIRRFGQKND KGTYYLSKVR MGLIVSIFNI
GCAIGGIVLS KVGDIYGRRI GLITVTAIYV VGILIQITSI NKWYQYFIGR IISGLGVGGI
AVLSPMLISE VAPKHIRGTL VQLYQLMGTM GIFLGYCTNY GTKNYHNATQ WRVGLGLCFA
WATFMVSGMM FVPESPRYLI EVGKDEEAKR SLSKSNKVSV DDPALLVEYD TIKAGIELEK
LAGNASWSEL LSTKTKVFQR VLMGVMIQSL QQLTGDNYFF YYGTTIFKSV GLKDSFQTSI
IIGVVNFFSS FIAVYTIERF GRRTCLLWGA ASMLCCFAVF ASVGVTKLWP QGSSHQDITS
QGAGNCMIVF TMFFIFSFAT TWAGGCYVIV SETFPLRVKS RGMAIATAAN WMWGFLISFF
TPFITGAINF YYGYVFLGCL VFAYFYVFFF VPETKGLTLE EVNTMWLEGV PAWKSASWVP
PERRTADYDA DAIDHDNRPI YKRFFSS
