HXT13_YEAST
ID HXT13_YEAST Reviewed; 564 AA.
AC P39924; D3DLI2;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=Hexose transporter HXT13;
GN Name=HXT13; Synonyms=HXT8; OrderedLocusNames=YEL069C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169868;
RA Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E.,
RA Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E.,
RA Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S.,
RA Hyman R.W., Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D.,
RA Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y.,
RA Botstein D., Davis R.W.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome V.";
RL Nature 387:78-81(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA Kim H., Melen K., Oesterberg M., von Heijne G.;
RT "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
CC -!- FUNCTION: Probable glucose transporter.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
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DR EMBL; U18795; AAB65018.1; -; Genomic_DNA.
DR EMBL; AY723801; AAU09718.1; -; Genomic_DNA.
DR EMBL; BK006939; DAA07586.1; -; Genomic_DNA.
DR PIR; S50520; S50520.
DR RefSeq; NP_010845.1; NM_001178884.1.
DR AlphaFoldDB; P39924; -.
DR SMR; P39924; -.
DR BioGRID; 36662; 61.
DR DIP; DIP-3943N; -.
DR IntAct; P39924; 1.
DR STRING; 4932.YEL069C; -.
DR TCDB; 2.A.1.1.110; the major facilitator superfamily (mfs).
DR PaxDb; P39924; -.
DR DNASU; 856640; -.
DR EnsemblFungi; YEL069C_mRNA; YEL069C; YEL069C.
DR GeneID; 856640; -.
DR KEGG; sce:YEL069C; -.
DR SGD; S000000795; HXT13.
DR VEuPathDB; FungiDB:YEL069C; -.
DR eggNOG; KOG0254; Eukaryota.
DR GeneTree; ENSGT00940000176280; -.
DR HOGENOM; CLU_001265_30_1_1; -.
DR InParanoid; P39924; -.
DR OMA; CCAVYAS; -.
DR BioCyc; YEAST:G3O-30184-MON; -.
DR PRO; PR:P39924; -.
DR Proteomes; UP000002311; Chromosome V.
DR RNAct; P39924; protein.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:SGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005351; F:carbohydrate:proton symporter activity; IBA:GO_Central.
DR GO; GO:0005353; F:fructose transmembrane transporter activity; IMP:SGD.
DR GO; GO:0005355; F:glucose transmembrane transporter activity; IMP:SGD.
DR GO; GO:0015578; F:mannose transmembrane transporter activity; IMP:SGD.
DR GO; GO:0008643; P:carbohydrate transport; IBA:GO_Central.
DR GO; GO:0008645; P:hexose transmembrane transport; IMP:SGD.
DR GO; GO:0015797; P:mannitol transmembrane transport; IGI:SGD.
DR GO; GO:0015795; P:sorbitol transmembrane transport; IGI:SGD.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00879; SP; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Repeat; Sugar transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..564
FT /note="Hexose transporter HXT13"
FT /id="PRO_0000050402"
FT TOPO_DOM 1..52
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..109
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 131..136
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..167
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..188
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 189..194
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 216..229
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 230..250
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 251..333
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 334..350
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 351..356
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 357..374
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 375..381
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 382..402
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 403..424
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 425..445
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 446..462
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 463..483
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 484
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 485..505
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 506..564
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 530..551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 564 AA; 62734 MW; AEFFFF691718AB44 CRC64;
MSSAQSSIDS DGDVRDADIH VAPPVEKEWS DGFDDNEVIN GDNVEPPKRG LIGYLVIYLL
CYPISFGGFL PGWDSGITAG FINMDNFKMN FGSYKHSTGE YYLSNVRMGL LVAMFSIGCA
IGGLIFARLA DTLGRRLAIV IVVLVYMVGA IIQISSNHKW YQYFVGKIIY GLGAGGCSVL
CPMLLSEIAP TDLRGGLVSL YQLNMTFGIF LGYCSVYGTR KYDNTAQWRV PLGLCFLWAL
IIIIGMLLVP ESPRYLIECE RHEEARASIA KINKVSPEDP WVLKQADEIN AGVLAQRELG
EASWKELFSV KTKVLQRLIT GILVQTFLQL TGENYFFFYG TTIFKSVGLT DGFETSIVLG
TVNFFSTIIA VMVVDKIGRR KCLLFGAAGM MACMVIFASI GVKCLYPHGQ DGPSSKGAGN
AMIVFTCFYI FCFATTWAPV AYIVVAESFP SKVKSRAMSI STACNWLWQF LIGFFTPFIT
GSIHFYYGYV FVGCLVAMFL YVFFFLPETI GLSLEEIQLL YEEGIKPWKS ASWVPPSRRG
ISSEESKTEK KDWKKFLKFS KNSD
