HXUA1_HAEIN
ID HXUA1_HAEIN Reviewed; 905 AA.
AC P44602;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Heme/hemopexin-binding protein;
DE AltName: Full=Heme:hemopexin utilization protein A;
DE Flags: Precursor;
GN Name=hxuA; OrderedLocusNames=HI_0264;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- FUNCTION: Binds heme/hemopexin complexes.
CC -!- SUBCELLULAR LOCATION: Secreted.
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DR EMBL; L42023; AAC21929.1; -; Genomic_DNA.
DR PIR; E64058; E64058.
DR RefSeq; NP_438433.1; NC_000907.1.
DR RefSeq; WP_005694039.1; NC_000907.1.
DR PDB; 4I84; X-ray; 1.50 A; A/B=24-324.
DR PDB; 4RM6; X-ray; 1.60 A; A=22-905.
DR PDB; 4RT6; X-ray; 2.80 A; A=22-905.
DR PDBsum; 4I84; -.
DR PDBsum; 4RM6; -.
DR PDBsum; 4RT6; -.
DR AlphaFoldDB; P44602; -.
DR SMR; P44602; -.
DR STRING; 71421.HI_0264; -.
DR PRIDE; P44602; -.
DR EnsemblBacteria; AAC21929; AAC21929; HI_0264.
DR KEGG; hin:HI_0264; -.
DR PATRIC; fig|71421.8.peg.279; -.
DR eggNOG; COG3210; Bacteria.
DR HOGENOM; CLU_320502_0_0_6; -.
DR OMA; NSHIKIV; -.
DR BioCyc; HINF71421:G1GJ1-279-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR Gene3D; 2.160.20.10; -; 1.
DR InterPro; IPR008638; Filamn_hemagglutn_N.
DR InterPro; IPR012334; Pectin_lyas_fold.
DR InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR Pfam; PF05860; Haemagg_act; 1.
DR SMART; SM00912; Haemagg_act; 1.
DR SUPFAM; SSF51126; SSF51126; 1.
DR TIGRFAMs; TIGR01901; adhes_NPXG; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome; Repeat; Secreted; Signal; Transport.
FT SIGNAL 1..21
FT /evidence="ECO:0000250"
FT CHAIN 22..905
FT /note="Heme/hemopexin-binding protein"
FT /id="PRO_0000021467"
FT STRAND 28..35
FT /evidence="ECO:0007829|PDB:4I84"
FT STRAND 37..42
FT /evidence="ECO:0007829|PDB:4I84"
FT STRAND 45..50
FT /evidence="ECO:0007829|PDB:4I84"
FT STRAND 52..61
FT /evidence="ECO:0007829|PDB:4I84"
FT STRAND 69..73
FT /evidence="ECO:0007829|PDB:4I84"
FT STRAND 80..85
FT /evidence="ECO:0007829|PDB:4I84"
FT STRAND 87..89
FT /evidence="ECO:0007829|PDB:4I84"
FT STRAND 91..93
FT /evidence="ECO:0007829|PDB:4I84"
FT STRAND 95..106
FT /evidence="ECO:0007829|PDB:4I84"
FT STRAND 111..113
FT /evidence="ECO:0007829|PDB:4I84"
FT STRAND 118..120
FT /evidence="ECO:0007829|PDB:4I84"
FT STRAND 122..130
FT /evidence="ECO:0007829|PDB:4I84"
FT STRAND 136..138
FT /evidence="ECO:0007829|PDB:4I84"
FT STRAND 144..146
FT /evidence="ECO:0007829|PDB:4I84"
FT STRAND 159..162
FT /evidence="ECO:0007829|PDB:4I84"
FT STRAND 164..167
FT /evidence="ECO:0007829|PDB:4I84"
FT STRAND 169..181
FT /evidence="ECO:0007829|PDB:4I84"
FT STRAND 183..186
FT /evidence="ECO:0007829|PDB:4I84"
FT STRAND 192..203
FT /evidence="ECO:0007829|PDB:4I84"
FT STRAND 208..212
FT /evidence="ECO:0007829|PDB:4I84"
FT HELIX 214..216
FT /evidence="ECO:0007829|PDB:4I84"
FT STRAND 222..225
FT /evidence="ECO:0007829|PDB:4I84"
FT STRAND 227..238
FT /evidence="ECO:0007829|PDB:4I84"
FT STRAND 242..245
FT /evidence="ECO:0007829|PDB:4I84"
FT STRAND 248..251
FT /evidence="ECO:0007829|PDB:4I84"
FT STRAND 253..257
FT /evidence="ECO:0007829|PDB:4I84"
FT STRAND 266..276
FT /evidence="ECO:0007829|PDB:4I84"
FT STRAND 281..291
FT /evidence="ECO:0007829|PDB:4I84"
FT STRAND 298..302
FT /evidence="ECO:0007829|PDB:4I84"
FT STRAND 307..323
FT /evidence="ECO:0007829|PDB:4I84"
FT TURN 337..340
FT /evidence="ECO:0007829|PDB:4RM6"
FT STRAND 345..349
FT /evidence="ECO:0007829|PDB:4RM6"
FT STRAND 356..361
FT /evidence="ECO:0007829|PDB:4RM6"
FT STRAND 366..369
FT /evidence="ECO:0007829|PDB:4RT6"
FT STRAND 372..375
FT /evidence="ECO:0007829|PDB:4RM6"
FT HELIX 376..385
FT /evidence="ECO:0007829|PDB:4RM6"
FT STRAND 386..391
FT /evidence="ECO:0007829|PDB:4RM6"
FT STRAND 396..404
FT /evidence="ECO:0007829|PDB:4RM6"
FT HELIX 407..409
FT /evidence="ECO:0007829|PDB:4RM6"
FT STRAND 412..416
FT /evidence="ECO:0007829|PDB:4RM6"
FT STRAND 422..433
FT /evidence="ECO:0007829|PDB:4RM6"
FT STRAND 435..438
FT /evidence="ECO:0007829|PDB:4RM6"
FT STRAND 443..445
FT /evidence="ECO:0007829|PDB:4RT6"
FT STRAND 451..468
FT /evidence="ECO:0007829|PDB:4RM6"
FT HELIX 473..475
FT /evidence="ECO:0007829|PDB:4RM6"
FT STRAND 479..481
FT /evidence="ECO:0007829|PDB:4RM6"
FT STRAND 484..487
FT /evidence="ECO:0007829|PDB:4RM6"
FT STRAND 492..523
FT /evidence="ECO:0007829|PDB:4RM6"
FT STRAND 528..532
FT /evidence="ECO:0007829|PDB:4RM6"
FT STRAND 535..540
FT /evidence="ECO:0007829|PDB:4RM6"
FT HELIX 549..553
FT /evidence="ECO:0007829|PDB:4RM6"
FT HELIX 571..578
FT /evidence="ECO:0007829|PDB:4RM6"
FT HELIX 580..582
FT /evidence="ECO:0007829|PDB:4RM6"
FT TURN 589..591
FT /evidence="ECO:0007829|PDB:4RT6"
FT STRAND 593..595
FT /evidence="ECO:0007829|PDB:4RT6"
FT STRAND 600..605
FT /evidence="ECO:0007829|PDB:4RM6"
FT STRAND 607..612
FT /evidence="ECO:0007829|PDB:4RM6"
FT STRAND 614..626
FT /evidence="ECO:0007829|PDB:4RM6"
FT STRAND 628..633
FT /evidence="ECO:0007829|PDB:4RM6"
FT HELIX 641..643
FT /evidence="ECO:0007829|PDB:4RM6"
FT STRAND 647..658
FT /evidence="ECO:0007829|PDB:4RM6"
FT STRAND 660..665
FT /evidence="ECO:0007829|PDB:4RM6"
FT STRAND 677..705
FT /evidence="ECO:0007829|PDB:4RM6"
FT STRAND 710..716
FT /evidence="ECO:0007829|PDB:4RM6"
FT HELIX 717..719
FT /evidence="ECO:0007829|PDB:4RM6"
FT STRAND 720..726
FT /evidence="ECO:0007829|PDB:4RM6"
FT STRAND 734..737
FT /evidence="ECO:0007829|PDB:4RT6"
FT STRAND 740..743
FT /evidence="ECO:0007829|PDB:4RT6"
FT TURN 744..751
FT /evidence="ECO:0007829|PDB:4RT6"
FT STRAND 753..757
FT /evidence="ECO:0007829|PDB:4RM6"
FT STRAND 761..769
FT /evidence="ECO:0007829|PDB:4RM6"
FT STRAND 771..775
FT /evidence="ECO:0007829|PDB:4RM6"
FT STRAND 781..785
FT /evidence="ECO:0007829|PDB:4RM6"
FT STRAND 789..793
FT /evidence="ECO:0007829|PDB:4RM6"
FT STRAND 797..802
FT /evidence="ECO:0007829|PDB:4RM6"
FT HELIX 824..834
FT /evidence="ECO:0007829|PDB:4RM6"
SQ SEQUENCE 905 AA; 98833 MW; 2424013EB437A99D CRC64;
MYKLNVISLI ILTTYTGATY ASARDLPQGS SVVVGEANVS TIGNKMTIDQ KTPTTQIDWH
SFDIGQNKEV EFKQPDANSV AYNRVTGGNA SQIQGKLTAN GKVYLANPNG VIITQGAEIN
VAGLFATTKD LERISENGNG NGNKFTRKLK DGQVVKEGQV INKGKIKAKD FVVLNGDKVI
NEGEIDATNN GKVYLSSGYN FTFTLSDSSI SVALEDNAVQ SIVQNEGIIK AGDITLNAKG
RNQALDSLVM NNGVLEATKV SNKNGKVVLS ADDVQLNNKS DIKGESEVVF TNEPKNKIKI
TSQTGSKVTS PKINFTGKSV NINGDFGRDD SKAHYNEEHK RLDTEVNIDV PDNENIRIAE
KDNTGTGTGT DSFIQTGALS SLLANNGKVN LKGKDVNISG RIHIDSFRGS DSLLKLTNQG
HIKINHADIH STGRLFFITS LQNEKDSQSD ITITDSKINL GNGAMGLGRS LDKENCDNQR
WCRTETSQRK KFDVHMRNVV FDQVDDVVVA GGFKKVNLDN IVATGKTNFY IDGGVSRNNS
RYEYGVLDLD KRTLLSELDQ RRRRWKYYND LDLDMNKAYW HRFDMFATKN TGRSTIKDTE
INISNSKINL KNGFVHLLAE KIKLDNSKID ITFDKDNSQD ISTQINRLGM NGKVSMVNSH
IKIVGDEKSD ISAKAPYATM FLIGELIGEK SSIFVKSHQG YTFRTDGDTK IAGKNSKDDL
KITAINTGGR TGKEVIINGA PGSIDNDANI ANMAFTIGDN ANTKTTIENA DITALAPNGG
TAYLSSKGVE IEVNPNSNFT FFELPREKNF NQTKIKGDST KLSERGFARL YDKINGVRAS
NLSAEQLNVT DASEKIINTK LVSSLDVEKL VSVAVCDAGK GCEEQQFGDK GNNTKVSVGE
LETEQ
