ID   HXUA2_HAEIF             Reviewed;         928 AA.
AC   P45354;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Heme/hemopexin-binding protein;
DE   AltName: Full=Heme:hemopexin utilization protein A;
DE   Flags: Precursor;
GN   Name=hxuA;
OS   Haemophilus influenzae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=727;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 22-35.
RC   STRAIN=DL42 / Serotype B;
RX   PubMed=7815944; DOI=10.1111/j.1365-2958.1994.tb00478.x;
RA   Cope L.D., Thomas S.E., Latimer J.L., Slaughter C.A., Mueller-Eberhard U.,
RA   Hansen E.J.;
RT   "The 100 kDa haem:haemopexin-binding protein of Haemophilus influenzae:
RT   structure and localization.";
RL   Mol. Microbiol. 13:863-873(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-30.
RC   STRAIN=DL42 / Serotype B;
RX   PubMed=7751272; DOI=10.1128/jb.177.10.2644-2653.1995;
RA   Cope L.D., Yogev R., Mueller-Eberhard U., Hansen E.J.;
RT   "A gene cluster involved in the utilization of both free heme and
RT   heme:hemopexin by Haemophilus influenzae type b.";
RL   J. Bacteriol. 177:2644-2653(1995).
CC   -!- FUNCTION: Binds heme/hemopexin complexes.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U08348; AAA74138.1; -; Genomic_DNA.
DR   PIR; S54699; S54699.
DR   RefSeq; WP_015701486.1; NZ_UEXC01000016.1.
DR   AlphaFoldDB; P45354; -.
DR   SMR; P45354; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.160.20.10; -; 1.
DR   InterPro; IPR008638; Filamn_hemagglutn_N.
DR   InterPro; IPR012334; Pectin_lyas_fold.
DR   InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR   Pfam; PF05860; Haemagg_act; 1.
DR   SMART; SM00912; Haemagg_act; 1.
DR   SUPFAM; SSF51126; SSF51126; 1.
DR   TIGRFAMs; TIGR01901; adhes_NPXG; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Repeat; Secreted; Signal; Transport.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000269|PubMed:7815944"
FT   CHAIN           22..928
FT                   /note="Heme/hemopexin-binding protein"
FT                   /id="PRO_0000021468"
FT   REPEAT          101..106
FT                   /note="1-1"
FT   REPEAT          149..154
FT                   /note="2-1"
FT   REPEAT          155..160
FT                   /note="2-2"
FT   REPEAT          161..166
FT                   /note="2-3"
FT   REPEAT          167..172
FT                   /note="2-4"
FT   REPEAT          205..210
FT                   /note="1-2"
FT   REPEAT          279..284
FT                   /note="1-3"
FT   REPEAT          410..415
FT                   /note="1-4"
FT   REPEAT          635..640
FT                   /note="1-5"
FT   REPEAT          674..679
FT                   /note="1-6"
FT   REGION          101..679
FT                   /note="6 X 6 AA approximate repeats"
FT   REGION          149..172
FT                   /note="4 X 6 AA approximate tandem repeats"
SQ   SEQUENCE   928 AA;  101228 MW;  67D45466A4B92390 CRC64;
     MYKLNVISLI ILTTCSGAAY ASTPDFPQHH KTVFGTVTIE KTTADKMTIK QGSDKAQIDW
     KSFDIGQKKE VKFEQPNEHA VAYNRVIGGN ASQIQGKLTA NGKVYLANPN GVIITQGAEI
     NVAGLLATTK DLERISENSN SYQFTRRTKD RQVLKEGLVL KDGQVVKEGQ VINEGNITAQ
     DFVVLNGDEV INKGNINVEK NSTINGKVYL SSGYNFTFTL PDSGISVALE DNTVQGIVKN
     EGSIKAGEIT LSAKGRKQAL DSLVMNNGVL EATKVSNKNG KVVLSADNVE LNNESNIKGE
     IVTFGADVTS NKELKDNIKI TSKTGSKVTS PKINFTGKSV NINGNFGRED STTHYKDEFK
     KLNTEVNIDV PDNENIRIAD IEDNTGTGTT GTGTSSFIQT GALSSLLANN GKVNLKGNNV
     NISGRIHIDS FRGSDSLLKL TNKGHIDINN ADIHSKGRLF FITSLQNEED FKSNITITDS
     KINLGNGAMG LGRSVDEKDY DNRWQKTEGS QRKKFDVKMS NVEFNQVDDV ILAGGFEKVN
     LDKIVATGQT NFYIDGGVSR NGRKYEYGVL DLDKRTQLSE LNQGRRRWGY YYDLELDMNR
     AYLYRFDLFA TKNTGRSTIK DTEINISNSN INLKNGFVHL LAEKIKLDNS KIDITFDKDN
     SQDTLAQTNR LGMNGKVSMI NSHIKIVGDE KEGISPTGTY ATMFLIGELI GEKSSIFVKS
     HQGYTFKTDG NTKIAGKYSK EDLKITAINT GGRAAEEVLI NGALGSADND ANIANMAFTI
     GDSANTKTTI ENADITALAP NGGTAYLSSK DVEIEVKPNS NFTFFELPRE KNLNQTKING
     ASTKLSERGF ARLYDKINGV RASNLSAEQL NVTDASEKII NTKLVSSLDV EKLVSVAVCD
     AGNGCEEQQF GDKGNNTKVS VGELEAEQ