ID   HXUA3_HAEIF             Reviewed;         917 AA.
AC   P45355;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Heme/hemopexin-binding protein;
DE   AltName: Full=Heme:hemopexin utilization protein A;
DE   Flags: Precursor;
GN   Name=hxuA;
OS   Haemophilus influenzae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=727;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=NTHi N182;
RX   PubMed=7815944; DOI=10.1111/j.1365-2958.1994.tb00478.x;
RA   Cope L.D., Thomas S.E., Latimer J.L., Slaughter C.A., Mueller-Eberhard U.,
RA   Hansen E.J.;
RT   "The 100 kDa haem:haemopexin-binding protein of Haemophilus influenzae:
RT   structure and localization.";
RL   Mol. Microbiol. 13:863-873(1994).
CC   -!- FUNCTION: Binds heme/hemopexin complexes.
CC   -!- SUBCELLULAR LOCATION: Secreted.
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DR   EMBL; U08349; AAA74139.1; -; Genomic_DNA.
DR   AlphaFoldDB; P45355; -.
DR   SMR; P45355; -.
DR   PRIDE; P45355; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.160.20.10; -; 1.
DR   InterPro; IPR008638; Filamn_hemagglutn_N.
DR   InterPro; IPR012334; Pectin_lyas_fold.
DR   InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR   Pfam; PF05860; Haemagg_act; 1.
DR   SMART; SM00912; Haemagg_act; 1.
DR   SUPFAM; SSF51126; SSF51126; 1.
DR   TIGRFAMs; TIGR01901; adhes_NPXG; 1.
PE   3: Inferred from homology;
KW   Repeat; Secreted; Signal; Transport.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000250"
FT   CHAIN           22..917
FT                   /note="Heme/hemopexin-binding protein"
FT                   /id="PRO_0000021469"
FT   REPEAT          24..28
FT                   /note="1-1"
FT   REPEAT          29..33
FT                   /note="1-2"
FT   REPEAT          34..38
FT                   /note="1-3"
FT   REPEAT          111..116
FT                   /note="2-1"
FT   REPEAT          159..164
FT                   /note="3-1"
FT   REPEAT          165..170
FT                   /note="3-2"
FT   REPEAT          203..208
FT                   /note="2-2"
FT   REPEAT          277..282
FT                   /note="2-3"
FT   REPEAT          399..404
FT                   /note="2-4"
FT   REPEAT          624..629
FT                   /note="2-5"
FT   REPEAT          663..668
FT                   /note="2-6"
FT   REGION          24..38
FT                   /note="3 X 5 AA tandem repeats"
FT   REGION          111..668
FT                   /note="6 X 6 AA approximate repeats"
FT   REGION          159..170
FT                   /note="2 X 6 AA approximate tandem repeats"
SQ   SEQUENCE   917 AA;  100149 MW;  7FF39BB8C046539D CRC64;
     MYKLNVISLI ILTTYTGAAY ASTQGLPQQG LPQQGLPQED KVVVGQATFD KTIADKMTIN
     QTSDKVQINW HSFDIGQNKE VEFKQPSENS VAYNRVTGGN ASQIQGKLTA NGKVYLANPN
     GVIITKGAEI NVAGLLATTK DLEQISENSN SYQFTRKTKD RQVVKEGQVI NEGEIKAKDF
     VVLNGDEVIN KGNINVEKNS TINGKVYLSS GYNFTFTLSD SGISVALEDN TVRGIVQNEG
     SIKAGEITLS AKGRKEALDS LVMNNGVLEA TKVSNRNGKV VLSADNVQLN NESNIKGEIV
     NFGTEVTSNE DKKLKITSKT GSKVTSPKIN FKGKSVNING NFGRENSGTH YNEERKTLNT
     EVNIDVPGAE NIRIADDKDN TETDSFIQTE ALSSLLANNG KVNLKGNDVN ISGNINIDSF
     RGTDSLLKLT NQGHINIDHA DINSKGRLFV VTSLQNDVDF KSNITITDSK INLGNGAMGL
     GRSVNEDDYA TRWKRAEKSQ RKKFNVDMRN VVFNQVDEVI LAGGFEKVNL DKIVATGQTN
     FYIDGGVSRN NSRYEYGVLD LDYRTQLSEL EQGRRRWRYY RDLDLDMNKA YLYRFDLFAK
     NNSGRSTIKG TEINISNSNI NLKNGFVHLL AENIKLDNSK VDITFDKDNS QDTLAQTNRL
     GMNGKVSMIN SHIKIVGDEK EGISPTGTYA TMFLIGELIG EKSSIFVKSH QGYTFKTDGD
     TKIAGKNSKE DLKITAINTG GRAAEEVLIN GALGSADNDA NIANMAFTIG DSANTKTTIE
     NADITALAPN GGTAYLSSKD VEIEVKPNSN FTFFELPREK NLNQTKINGA STKLSERGFA
     RLYDKINGVR ASNLSAEQLN VTDASEKIIN TKLVSSLDVE KLVSVAVCDA GNGCEEQQFG
     DKGNNTKVSV GELEAEQ