ID   HXUB1_HAEIN             Reviewed;         565 AA.
AC   P44601;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Heme/hemopexin transporter protein HuxB;
DE   Flags: Precursor;
GN   Name=hxuB; OrderedLocusNames=HI_0263;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Likely functions in the release of soluble HxuA from the
CC       cell. {ECO:0000250}.
CC   -!- FUNCTION: Probable member of a two partner secretion pathway (TPS) in
CC       which it mediates the secretion of HuxA. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane.
CC   -!- DOMAIN: Probably a beta-barrel protein. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TPS (TC 1.B.20) family. {ECO:0000305}.
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DR   EMBL; L42023; AAC21928.1; -; Genomic_DNA.
DR   PIR; D64058; D64058.
DR   RefSeq; NP_438432.1; NC_000907.1.
DR   RefSeq; WP_005694040.1; NC_000907.1.
DR   AlphaFoldDB; P44601; -.
DR   SMR; P44601; -.
DR   STRING; 71421.HI_0263; -.
DR   PRIDE; P44601; -.
DR   EnsemblBacteria; AAC21928; AAC21928; HI_0263.
DR   KEGG; hin:HI_0263; -.
DR   PATRIC; fig|71421.8.peg.278; -.
DR   eggNOG; COG2831; Bacteria.
DR   HOGENOM; CLU_021521_2_2_6; -.
DR   OMA; TIRTPNF; -.
DR   PhylomeDB; P44601; -.
DR   BioCyc; HINF71421:G1GJ1-278-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0098046; C:type V protein secretion system complex; IBA:GO_Central.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0008320; F:protein transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0046819; P:protein secretion by the type V secretion system; IBA:GO_Central.
DR   InterPro; IPR005565; Hemolysn_activator_HlyB_C.
DR   InterPro; IPR013686; Polypept-transport_assoc_ShlB.
DR   InterPro; IPR034746; POTRA.
DR   Pfam; PF08479; POTRA_2; 1.
DR   Pfam; PF03865; ShlB; 1.
DR   PROSITE; PS51779; POTRA; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Ion transport; Membrane; Porin; Protein transport;
KW   Reference proteome; Signal; Transmembrane; Transmembrane beta strand;
KW   Transport.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000250"
FT   CHAIN           27..565
FT                   /note="Heme/hemopexin transporter protein HuxB"
FT                   /id="PRO_0000021470"
FT   DOMAIN          73..150
FT                   /note="POTRA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01115"
SQ   SEQUENCE   565 AA;  62824 MW;  B83F82558F7F5A91 CRC64;
     MKMRPRYSVI ASAVSLGFVL SKSVMALDRP DTGSLNRELE QRQIQSEAKP SGELFNQTAN
     SPYTAQYKQG LKFPLKQVQI LDRNNQEVVT DELAHILKNY VGKEVSLSDL SNLANEISEF
     YRHNNYLVAK AILPPQEIEQ GTVKILLLKG NVGEIRLQNH SALSNKFVSR LSNTTVNASE
     FILKDELEKF ALTINDVPGV NAGLQLSAGK KVGEANLLIK INDAKRFSSY VSVDNQGNKY
     TGRYRLAAGT KVSNLNGWGD ELKLDLMSSN QANLKNARID YSSLIDGYST RFGVTANYLD
     YKLGGNFKSL QSQGHSHTLG AYLLHPTIRT PNFRLSTKVS FNHQNLTDKQ QAVYVKQKRK
     INSLTAGIDG SWNLIKDGTT YFSLSTLFGN LANQTSEKKQ YTKEDFQPQS HFTVYNYRLS
     HEQILPKSFA FNIGINGQFA DKTLESSQKM LLGGLSGVRG HQAGAASVDE GHLIQTEFKH
     YLPVFSQSVL VSSLFYDYGL GKYYKNSQFL EKGVKNSVKL QSVGAGLSLS DAGSYAINVS
     VAKPLDNNIN NADKHQFWLS MIKTF