ID   HXUB2_HAEIF             Reviewed;         565 AA.
AC   P45356;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Heme/hemopexin transporter protein HuxB;
DE   Flags: Precursor;
GN   Name=hxuB;
OS   Haemophilus influenzae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=727;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PARTIAL PROTEIN SEQUENCE.
RC   STRAIN=DL42 / Serotype B;
RX   PubMed=7751272; DOI=10.1128/jb.177.10.2644-2653.1995;
RA   Cope L.D., Yogev R., Mueller-Eberhard U., Hansen E.J.;
RT   "A gene cluster involved in the utilization of both free heme and
RT   heme:hemopexin by Haemophilus influenzae type b.";
RL   J. Bacteriol. 177:2644-2653(1995).
CC   -!- FUNCTION: Likely functions in the release of soluble HxuA from the
CC       cell.
CC   -!- FUNCTION: Probable member of a two partner secretion pathway (TPS) in
CC       which it mediates the secretion of HuxA. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane.
CC   -!- DOMAIN: Probably a beta-barrel protein. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TPS (TC 1.B.20) family. {ECO:0000305}.
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DR   EMBL; U09840; AAA87060.1; -; Genomic_DNA.
DR   PIR; B57148; B57148.
DR   AlphaFoldDB; P45356; -.
DR   SMR; P45356; -.
DR   TCDB; 1.B.20.3.1; the two-partner secretion (tps) family.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR005565; Hemolysn_activator_HlyB_C.
DR   InterPro; IPR013686; Polypept-transport_assoc_ShlB.
DR   InterPro; IPR034746; POTRA.
DR   Pfam; PF08479; POTRA_2; 1.
DR   Pfam; PF03865; ShlB; 1.
DR   PROSITE; PS51779; POTRA; 1.
PE   1: Evidence at protein level;
KW   Cell outer membrane; Direct protein sequencing; Ion transport; Membrane;
KW   Porin; Protein transport; Signal; Transmembrane; Transmembrane beta strand;
KW   Transport.
FT   SIGNAL          1..26
FT   CHAIN           27..565
FT                   /note="Heme/hemopexin transporter protein HuxB"
FT                   /id="PRO_0000021471"
FT   DOMAIN          73..150
FT                   /note="POTRA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01115"
SQ   SEQUENCE   565 AA;  62641 MW;  5BB77AF588DC2403 CRC64;
     MKMRPRYSVI ASAVSLGFVL SKSVMALGQP DTGSLNRELE QRQIQSEAKP SGELFNQTAN
     SPYTAQYKQG LKFPLTQVQI LDRNNQEVVT DELAHILKNY VGKEVSLSDL SNLANEISEF
     YRHNNYLVAK AILPPQEIEQ GTVKILLLKG NVGEIRLQNH SALSNKFVSR LSNTTVNTSE
     FILKDELEKF ALTINDVPGV NAGLQLSAGK KVGEANLLIK INDAKRFSSY VSVDNQGNKY
     TGRYRLAAGT KVSNLNGWGD ELKLDLMSSN QANLKNARID YSSLIDGYST RFGVTANYLD
     YKLGGNFKSL QSQGHSHTLG AYLLHPTIRT PNFRLSTKVS FNHQNLTDKQ QAVYVKQKRK
     INSLTAGIDG SWNLIKDGTT YFSLSTLFGN LANQTSEKKH NAVENFQPKS HFTVYNYRLS
     HEQILPKSFA FNIGINGQFA DKTLESSQKM LLGGLSGVRG HQAGAASVDE GHLIQTEFKH
     YLPVFSQSVL VSSLFYDYGL GKYYKNSQFL EQGVKNSVKL QSVGAGLSLS DAGSYAINVS
     VAKPLDNNIN NADKHQFWLS MIKTF