ID   HXUB_HAEI8              Reviewed;         565 AA.
AC   Q4QNS5;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Heme/hemopexin transporter protein HuxB;
DE   Flags: Precursor;
GN   Name=hxuB; OrderedLocusNames=NTHI0370;
OS   Haemophilus influenzae (strain 86-028NP).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=281310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=86-028NP;
RX   PubMed=15968074; DOI=10.1128/jb.187.13.4627-4636.2005;
RA   Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B.,
RA   Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O.,
RA   Munson R.S. Jr.;
RT   "Genomic sequence of an otitis media isolate of nontypeable Haemophilus
RT   influenzae: comparative study with H. influenzae serotype d, strain KW20.";
RL   J. Bacteriol. 187:4627-4636(2005).
CC   -!- FUNCTION: Likely functions in the release of soluble HxuA from the
CC       cell. {ECO:0000250}.
CC   -!- FUNCTION: Probable member of a two partner secretion pathway (TPS) in
CC       which it mediates the secretion of HuxA. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}.
CC   -!- DOMAIN: Probably a beta-barrel protein. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TPS (TC 1.B.20) family. {ECO:0000305}.
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DR   EMBL; CP000057; AAX87322.1; -; Genomic_DNA.
DR   RefSeq; WP_011271953.1; NC_007146.2.
DR   AlphaFoldDB; Q4QNS5; -.
DR   SMR; Q4QNS5; -.
DR   EnsemblBacteria; AAX87322; AAX87322; NTHI0370.
DR   KEGG; hit:NTHI0370; -.
DR   HOGENOM; CLU_021521_2_2_6; -.
DR   OMA; TIRTPNF; -.
DR   OrthoDB; 956274at2; -.
DR   Proteomes; UP000002525; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR005565; Hemolysn_activator_HlyB_C.
DR   InterPro; IPR013686; Polypept-transport_assoc_ShlB.
DR   InterPro; IPR034746; POTRA.
DR   Pfam; PF08479; POTRA_2; 1.
DR   Pfam; PF03865; ShlB; 1.
DR   PROSITE; PS51779; POTRA; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Ion transport; Membrane; Porin; Protein transport;
KW   Signal; Transmembrane; Transmembrane beta strand; Transport.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000250"
FT   CHAIN           27..565
FT                   /note="Heme/hemopexin transporter protein HuxB"
FT                   /id="PRO_0000230982"
FT   DOMAIN          73..150
FT                   /note="POTRA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01115"
SQ   SEQUENCE   565 AA;  62748 MW;  4E0F0442C860CFD9 CRC64;
     MKMRPRYSVI ASAVSLGFVL SKSVMALGQP DTGSLNRELE QRRIQPEAKP SGELFNQAAK
     SPYTAQYKQE LKFPLTQVQI LDRNNQEVVT DELAHILKNY VGKEVSLSDL SNLANEISEF
     YRNNNYLVAK AILPPQEIEQ GTVKILLLKG NVGEIRLQNH SALSNKFVSR LSNTTVNTSE
     FILKDELEKF ALTINDVPGV NAGLQLSAGK KVGEANLLIK INDAKRFSSY VSVDNQGNKY
     TGRYRLAAGT KVNNLTGWGD ELKLDLLSSN QANLKNARID YSSLIDGYST RFGVTANYLH
     YKLGGNFKSL QSQGHSHNLG AYLLHPTIRT PNFRLSTKVS FNHQNLTDEQ QAVTVKQKRK
     INSLTVGIDG SWNLIKDGTT YFSLSTLFGN LANQTNEKKH NAKEDFQPQS HFTVYNYRLS
     HEQILPKSFA FNIGINGQFA DKTLESSQKM LLGGLSGVRG HQAGAASVDE GHLIQTEFKH
     YLPVFSQSVL VSSLFYDYGF GKYYKNSQSL AQSVKNSVKL QSVGAGLSFS DAGSYAINVS
     VAKPLDNNID NADKHQFWLS MIKTF