ID   HXUC1_HAEIN             Reviewed;         723 AA.
AC   P44600;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=Heme/hemopexin utilization protein C;
DE   Flags: Precursor;
GN   Name=hxuC; OrderedLocusNames=HI_0262;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=10675023;
RX   DOI=10.1002/(sici)1522-2683(20000101)21:2<411::aid-elps411>3.0.co;2-4;
RA   Langen H., Takacs B., Evers S., Berndt P., Lahm H.W., Wipf B., Gray C.,
RA   Fountoulakis M.;
RT   "Two-dimensional map of the proteome of Haemophilus influenzae.";
RL   Electrophoresis 21:411-429(2000).
CC   -!- FUNCTION: Required for utilization of free heme at low concentrations.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TonB-dependent receptor family.
CC       {ECO:0000305}.
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DR   EMBL; L42023; AAC21927.1; -; Genomic_DNA.
DR   PIR; C64058; C64058.
DR   RefSeq; NP_438431.1; NC_000907.1.
DR   RefSeq; WP_005694042.1; NC_000907.1.
DR   AlphaFoldDB; P44600; -.
DR   SMR; P44600; -.
DR   STRING; 71421.HI_0262; -.
DR   TCDB; 1.B.14.2.11; the outer membrane receptor (omr) family.
DR   EnsemblBacteria; AAC21927; AAC21927; HI_0262.
DR   KEGG; hin:HI_0262; -.
DR   PATRIC; fig|71421.8.peg.277; -.
DR   eggNOG; COG4771; Bacteria.
DR   HOGENOM; CLU_008287_19_3_6; -.
DR   OMA; AWEVGFN; -.
DR   PhylomeDB; P44600; -.
DR   BioCyc; HINF71421:G1GJ1-277-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031230; C:intrinsic component of cell outer membrane; IBA:GO_Central.
DR   GO; GO:0015232; F:heme transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015344; F:siderophore uptake transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0044718; P:siderophore transmembrane transport; IBA:GO_Central.
DR   Gene3D; 2.170.130.10; -; 1.
DR   Gene3D; 2.40.170.20; -; 1.
DR   InterPro; IPR039426; BtuB-like.
DR   InterPro; IPR012910; Plug_dom.
DR   InterPro; IPR037066; Plug_dom_sf.
DR   InterPro; IPR000531; TonB-dep_rcpt_b-brl.
DR   InterPro; IPR011276; TonB_haem/Hb_rcpt.
DR   InterPro; IPR010949; TonB_Hb/transfer/lactofer_rcpt.
DR   InterPro; IPR036942; TonB_rcpt_b-brl_sf.
DR   InterPro; IPR010917; TonB_rcpt_CS.
DR   PANTHER; PTHR30069; PTHR30069; 1.
DR   Pfam; PF07715; Plug; 1.
DR   Pfam; PF00593; TonB_dep_Rec; 1.
DR   TIGRFAMs; TIGR01785; TonB-hemin; 1.
DR   TIGRFAMs; TIGR01786; TonB-hemlactrns; 1.
DR   PROSITE; PS01156; TONB_DEPENDENT_REC_2; 1.
PE   1: Evidence at protein level;
KW   Cell outer membrane; Membrane; Reference proteome; Signal; TonB box;
KW   Transmembrane; Transmembrane beta strand.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..723
FT                   /note="Heme/hemopexin utilization protein C"
FT                   /id="PRO_0000034792"
FT   MOTIF           706..723
FT                   /note="TonB C-terminal box"
SQ   SEQUENCE   723 AA;  80776 MW;  91EB3AB0FFEA2984 CRC64;
     MRFSKLSLAI TTTLVTANAL AQSVELDSIN VIATRDPSRF AYTPEKQSKD SLLSKQATSV
     ADALEDIPNV DVRGGSRSIA QKPNIRGLSD NRVVQVIDGV RQNFDLAHRG SYFLPMSLIQ
     EIEVIKGPSS SLWGSGALGG VVAMRTPNAL DLLKNNDKFG VKIRQGYQTA NNLSEKDVSV
     FAANDKFDVL ISGFYNNADN LRTGKGNKLN NTAYKQFGGL AKFGWQINDA NRVELSHRET
     RFKQTAPSNN EVENELTNEQ ITDQIKKFHG QKDDLLPPTT QPSPSERSEF YSKVKTRLGS
     VSYLTDQQIP DQSTVFNYYL TPDNPYLNTH IALYNNKTIE KEQRKVSGVK DQTKLTTRGI
     NLRNSSELSH ISFVYGVDYM RDKIRTERGT NGSDAKFRAD PYNANSNTTG VYLIAHIPLF
     GEKLLVSPSV RYDHYDTSSK TVKYKDNHLS PATKLTWIVT NWLDFTAKYN EAFRAPSMQE
     RFVSGAHFGA NTLGLDHINR FVANPNLRPE TAKNKEITAN LHFDSLFKQG DKFKIEATYF
     RNDVKDFINL KIFNDAKTSA SAGANPNTNG ALLPKNSQYQ NITNARLSGI ELQAQYQTER
     LTLFTNYGST KGKDKDSGEA LSNIAASKIG VGVNYALVKD KFTVGATVTH YAAQRRVPKD
     HSVTYPSYIL TDLRATYAPL KGEWKNLRLD FALENLFDRK YQPAFSLMEG TGRNAKISAV
     YSF